Comparison between HIV self-testing and facility-based HIV testing approach on HIV early detection among men who have sex with men: A cross-sectional study

Public Deposited
Analytics

Downloadable Content

Download PDF
Request Version for Screen Reader
Creator
  • Zhou, Yi
    • Other Affiliation: Zhuhai Center for Disease Control and Prevention
  • Huang, Shaoli
    • Other Affiliation: Zhejiang University
  • Cui, Mingting
    • Other Affiliation: Sun Yat-sen University
  • Guo, Zhihui
    • Other Affiliation: Sun Yat-sen University
  • Tang, Haotong
    • Other Affiliation: Macau University of Science and Technology
  • Lyu, Hang
    • Other Affiliation: Zhuhai Center for Disease Control and Prevention
  • Ni, Yuxin
    • Affiliation: School of Medicine, UNC Project-China
  • Lu, Ying
    • Affiliation: School of Medicine, UNC Project-China
  • Feng, Yunlong
    • Other Affiliation: Jinan University
  • Wang, Yuyu
    • Other Affiliation: Jinan University
  • Jing, Fengshi
    • Other Affiliation: Guangdong Second Provincial General Hospital
  • Huang, Shanzi
    • Other Affiliation: Zhuhai Center for Disease Control and Prevention
  • Li, Jiarun
    • Other Affiliation: Zhuhai Center for Disease Control and Prevention
  • Xu, Yao
    • Other Affiliation: Monash University
  • Mei, Wenhua
    • Other Affiliation: Zhuhai Center for Disease Control and Prevention
Abstract
  • Background To assess whether HIV self-testing (HIVST) has a better performance in identifying HIV-infected cases than the facility-based HIV testing (HIVFBT) approach. Methods A cross-sectional study was conducted among men who have sex with men (MSM) by using an online questionnaire (including information on sociodemographic, sexual biography, and HIV testing history) and blood samples (for limiting antigen avidity enzyme immunoassay, gene subtype testing, and taking confirmed HIV test). MSM who were firstly identified as HIV positive through HIVST and HIVFBT were compared. Chi-square or Fisher’s exact test was used to explore any association between both groups and their subgroups. Results In total, 124 MSM HIV cases were identified from 2017 to 2021 in Zhuhai, China, including 60 identified through HIVST and 64 through HIVFBT. Participants in the HIVST group were younger (≤30 years, 76.7% vs. 46.9%), were better educated (>high school, 61.7% vs. 39.1%), and had higher viral load (≥1,000 copies/ml, 71.7% vs. 50.0%) than MSM cases identified through HIVFBT. The proportion of early HIV infection in the HIVST group was higher than in the HIVFBT group, identified using four recent infection testing algorithms (RITAs) (RITA 1, 46.7% vs. 25.0%; RITA 2, 43.3% vs. 20.3%; RITA 3, 30.0% vs. 14.1%; RITA 4, 26.7% vs. 10.9%; all p < 0.05). Conclusions The study showed that HIVST has better HIV early detection among MSM and that recent HIV infection cases mainly occur in younger and better-educated MSM. Compared with HIVFBT, HIVST is more accessible to the most at-risk population on time and tends to identify the case early. Further implementation studies are needed to fill the knowledge gap on this medical service model among MSM and other target populations.
Date of publication
Keyword
DOI
Identifier
Resource type
  • Article
Rights statement
  • In Copyright
License
  • Attribution 4.0 International
Journal title
  • Frontiers in Immunology
Journal volume
  • 13
Language
  • English
Version
  • Publisher
ISSN
  • 1664-3224

Relations

Parents:

This work has no parents.

In Collection:

Items

Thumbnail Title Date Uploaded Visibility Actions
file details fimmu-13-857905.pdf 2022-10-07 Public Download