Breast cancer brain metastases: evidence for neuronal-like adaptation in a ‘breast-to-brain’ transition? Public Deposited
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Siegel, Marni B
- Affiliation: School of Medicine, Department of Genetics, N.C. Cancer Hospital, UNC Lineberger Comprehensive Cancer Center
- Affiliation: School of Medicine, Division of Hematology/Oncology, N.C. Cancer Hospital, UNC Lineberger Comprehensive Cancer Center, Department of Medicine
Van Swearingen, Amanda E
- Affiliation: N.C. Cancer Hospital, UNC Lineberger Comprehensive Cancer Center, School of Medicine
- Abstract Brain metastases remain a significant challenge in the treatment of breast cancer patients due to the unique environment posed by the central nervous system. A better understanding of the biology of breast cancer cells that have metastasized to the brain is required to develop improved therapies. A recent Proceedings of the National Academy of Sciences article demonstrates that breast cancer cells in the brain microenvironment express γ-aminobutyric acid (GABA)-related genes, enabling them to utilize GABA as an oncometabolite, thus gaining a proliferative advantage. In this viewpoint, we highlight these findings and their potential impact on the treatment of breast cancer brain metastases.
- Date of publication
- May 6, 2014
- Resource type
- Rights statement
- In Copyright
- Rights holder
- Van Swearingen et al.; license BioMed Central Ltd.
- Bibliographic citation
- Breast Cancer Research. 2014 May 06;16(3):304
- BioMed Central
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