UDP-Sugars as Extracellular Signaling Molecules: Cellular and Physiologic Consequences of P2Y14 Receptor Activation
Public Deposited- Creator
- Lazarowski, E. R.
- Harden, T. K.
- Abstract
- UDP-sugars, which are indispensable for protein glycosylation reactions in cellular secretory pathways, also act as important extracellular signaling molecules. We discuss here the broadly expressed P2Y14 receptor, a G-protein–coupled receptor targeted by UDP sugars, and the increasingly diverse set of physiologic responses discovered recently functioning downstream of this receptor in many epithelia as well as in immune, inflammatory, and other cells.
- Date of publication
- 2015
- Keyword
- DOI
- Identifier
- PMCID: PMC4468635
- Publisher DOI: https://doi.org/10.1124/mol.115.098756
- PMID: 25829059
- Onescience id: 787b5b8c0dbdaee2f9c527db10aaa468ca54f0c6
- Resource type
- Article
- Rights statement
- In Copyright
- Journal title
- Molecular Pharmacology
- Journal volume
- 88
- Journal issue
- 1
- Page start
- 151
- Page end
- 160
- Language
- English
- ISSN
- 1521-0111
- 0026-895X
Relations
- Parents:
This work has no parents.
Items
| Thumbnail | Title | Date Uploaded | Visibility | Actions |
|---|---|---|---|---|
|
|
EuropePMC-PMC4468635.pdf | October 31, 2020 | Public | Download |