Sensing unsaturated fatty acids: insights from GPR120 signaling

Public Deposited
Analytics

Downloadable Content

Download PDF
Request Version for Screen Reader
Creator
  • Zhang S
    • School of Medicine, Department of Pharmacology
  • Roth B.L
    • School of Medicine, Department of Pharmacology
Abstract
  • GPR120 is a receptor that plays a crucial role in mediating the beneficial effects of free fatty acids (FAs), particularly ω-3 FAs, on metabolic and inflammatory pathways, making it an important therapeutic target for metabolic diseases. Recently, Mao et al. report the cryo-EM structures of GPR120 in complex with an ω-3 FA as well as other three endogenous FAs and a synthetic agonist, along with pharmacological investigations and molecular dynamics simulations, thereby providing comprehensive insights into the molecular recognition and biased signaling of GPR120 via various agonists
Date of publication
Keyword
DOI
Identifier
Resource type
  • Article
Rights statement
  • In Copyright
Journal title
  • Cell Research
Journal volume
  • 33
Journal issue
  • 9
Page start
  • 657
Page end
  • 658
Language
  • English
ISSN
  • 1001-0602
Publisher
  • Springer Nature

Relations

Parents:

This work has no parents.

In Collection:

Items

Thumbnail Title Date Uploaded Visibility Actions
file details s41422-023-00814-2.pdf 2024-06-06 Public Download