Agonist-receptor efficacy II: agonist trafficking of receptor signals Public Deposited

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  • Kenakin, Terry
    • Other Affiliation: Department of Cellular Biochemistry, Glaxo Research Institute, Five Moore Drive, PO Box 13358, Research Triangle Park, NC 27709, USA
Abstract
  • There is evidence to suggest that receptors with seven transmembrane domains can exist in G protein-activating conformations. It is not known how many activated receptor forms exist for each receptor. Furthermore, if there are multiple forms, does the chemical structure of the agonist determine which form dominates, and therefore, which response pathway is activated? This latter scheme is referred to as agonist-receptor trafficking, and is discussed in this, the second of two articles by Terry Kenakin. One way to approach these questions is to study receptors that couple to more than one G protein and, in essence, to try to allow the G protein to indicate the receptor state.
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Resource type
  • Article
Rights statement
  • In Copyright
Journal title
  • Trends in Pharmacological Sciences
Journal volume
  • 16
Journal issue
  • 7
Page start
  • 232
Page end
  • 238
Language
  • English
Version
  • Postprint
ISSN
  • 0165-6147
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