Nanomicelles of Radium Dichloride [223Ra]RaCl2 Co-Loaded with Radioactive Gold [198Au]Au Nanoparticles for Targeted Alpha–Beta Radionuclide Therapy of Osteosarcoma

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  • Souza, Bárbara Nayane Rosário Fernandes
    • Other Affiliation: Brazilian Nuclear Energy Commission
  • Ribeiro, Elisabete Regina Fernandes Ramos
    • Other Affiliation: Brazilian Nuclear Energy Commission
  • da Silva de Barros, Aline Oliveira
    • Other Affiliation: Brazilian Nuclear Energy Commission
  • Pijeira, Martha Sahylí Ortega
    • Other Affiliation: Brazilian Nuclear Energy Commission
  • Kenup-Hernandes, Hericka Oliveira
    • Other Affiliation: Brazilian Nuclear Energy Commission
  • Ricci-Junior, Eduardo
    • Other Affiliation: Universidade Federal do Rio de Janeiro
  • Diniz Filho, Joel Félix Silva
    • Other Affiliation: Federal University of Maranhão
  • dos Santos, Clenilton Costa
    • Other Affiliation: Federal University of Maranhão
  • Alencar, Luciana Magalhães Rebelo
    • Other Affiliation: Federal University of Maranhão
  • Attia, Mohamed F.
    • Eshelman School of Pharmacy, Center for Nanotechnology in Drug Delivery
  • Gemini-Piperni, Sara
    • Other Affiliation: Universidade Federal do Rio de Janeiro
  • Santos-Oliveira, Ralph
    • Other Affiliation: Brazilian Nuclear Energy Commission
Abstract
  • Alpha and beta particulate radiation are used for non-treated neoplasia, due to their ability to reach and remain in tumor sites. Radium-223 (223Ra), an alpha emitter, promotes localized cytotoxic effects, while radioactive gold (198Au), beta-type energy, reduces radiation in the surrounding tissues. Nanotechnology, including several radioactive nanoparticles, can be safely and effectively used in cancer treatment. In this context, this study aims to analyze the antitumoral effects of [223Ra]Ra nanomicelles co-loaded with radioactive gold nanoparticles ([198Au]AuNPs). For this, we synthesize and characterize nanomicelles, as well as analyze some parameters, such as particle size, radioactivity emission, dynamic light scattering, and microscopic atomic force. [223Ra]Ra nanomicelles co-loaded with [198Au]AuNPs, with simultaneous alpha and beta emission, showed no instability, a mean particle size of 296 nm, and a PDI of 0.201 (±0.096). Furthermore, nanomicelles were tested in an in vitro cytotoxicity assay. We observed a significant increase in tumor cell death using combined alpha and beta therapy in the same formulation, compared with these components used alone. Together, these results show, for the first time, an efficient association between alpha and beta therapies, which could become a promising tool in the control of tumor progression.
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  • Article
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  • In Copyright
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  • Attribution 3.0 United States
Journal title
  • Polymers
Journal volume
  • 14
Journal issue
  • 7
Page start
  • 1405
Language
  • English
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  • Publisher
ISSN
  • 2073-4360

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