Predictors of SARS-CoV-2 RNA From Nasopharyngeal Swabs and Concordance With Other Compartments in Nonhospitalized Adults With Mild to Moderate COVID-19
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Moser, Carlee, et al. Predictors of Sars-cov-2 Rna From Nasopharyngeal Swabs and Concordance With Other Compartments In Nonhospitalized Adults With Mild to Moderate Covid-19. Oxford University Press, 2022. https://doi.org/10.17615/vptt-dg28APA
Moser, C., Li, J., Eron, J., Aga, E., Daar, E., Wohl, D., Coombs, R., Javan, A., Bender Ignacio, R., Jagannathan, P., Ritz, J., Sieg, S., Parikh, U., Hughes, M., Currier, J., Smith, D., & Chew, K. (2022). Predictors of SARS-CoV-2 RNA From Nasopharyngeal Swabs and Concordance With Other Compartments in Nonhospitalized Adults With Mild to Moderate COVID-19. Oxford University Press. https://doi.org/10.17615/vptt-dg28Chicago
Moser, Carlee, Jonathan Z Li, Joseph J Eron, Evgenia Aga, Eric S Daar, David A Wohl, Robert W Coombs et al. 2022. Predictors of Sars-Cov-2 Rna From Nasopharyngeal Swabs and Concordance With Other Compartments In Nonhospitalized Adults With Mild to Moderate Covid-19. Oxford University Press. https://doi.org/10.17615/vptt-dg28- Creator
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Moser, Carlee
- Other Affiliation: Harvard T.H. Chan School of Public Health
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Li, Jonathan Z
- Other Affiliation: Harvard Medical School
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Eron, Joseph J
- Affiliation: School of Medicine, Department of Medicine
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Aga, Evgenia
- Other Affiliation: Harvard T.H. Chan School of Public Health
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Daar, Eric S
- Other Affiliation: Harbor-UCLA Medical Center
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Wohl, David A
- Affiliation: School of Medicine, Department of Medicine
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Coombs, Robert W
- Other Affiliation: University of Washington
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Javan, Arzhang Cyrus
- Other Affiliation: National Institutes of Health,
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Bender Ignacio, Rachel A
- Other Affiliation: University of Washington
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Jagannathan, Prasanna
- Other Affiliation: Stanford University
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Ritz, Justin
- Other Affiliation: Harvard T.H. Chan School of Public Health
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Sieg, Scott F
- Other Affiliation: Case Western University
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Parikh, Urvi M
- Other Affiliation: University of Pittsburgh
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Hughes, Michael D
- Other Affiliation: Harvard T.H. Chan School of Public Health
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Currier, Judith S
- Other Affiliation: University of California, Los Angeles
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Smith, Davey M
- Other Affiliation: University of California, San Diego
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Chew, Kara W
- Other Affiliation: University of California, Los Angeles
- Abstract
- Background Identifying characteristics associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA shedding may be useful to understand viral compartmentalization, disease pathogenesis, and risks for viral transmission. Methods Participants were enrolled August 2020 to February 2021 in ACTIV-2/A5401, a placebo-controlled platform trial evaluating investigational therapies for mild-to-moderate coronavirus disease 2019 (COVID-19), and underwent quantitative SARS-CoV-2 RNA testing on nasopharyngeal and anterior nasal swabs, oral wash/saliva, and plasma at entry (day 0, pretreatment) and days 3, 7, 14, and 28. Concordance of RNA levels (copies/mL) across compartments and predictors of nasopharyngeal RNA levels were assessed at entry (n = 537). Predictors of changes over time were evaluated among placebo recipients (n = 265) with censored linear regression models. Results Nasopharyngeal and anterior nasal RNA levels at study entry were highly correlated (r = 0.84); higher levels of both were associated with greater detection of RNA in plasma and oral wash/saliva. Older age, White non-Hispanic race/ethnicity, lower body mass index (BMI), SARS-CoV-2 immunoglobulin G seronegativity, and shorter prior symptom duration were associated with higher nasopharyngeal RNA at entry. In adjusted models, body mass index and race/ethnicity associations were attenuated, but the association with age remained (for every 10 years older, mean nasopharyngeal RNA was 0.27 log10 copies/mL higher; P < .001). Examining longitudinal viral RNA levels among placebo recipients, women had faster declines in nasopharyngeal RNA than men (mean change, −2.0 vs −1.3 log10 copies/mL, entry to day 3; P < .001). Conclusions SARS-CoV-2 RNA shedding was concordant across compartments. Age was strongly associated with viral shedding, and men had slower viral clearance than women, which could explain sex differences in acute COVID-19 outcomes.
- Date of publication
- 2022
- Keyword
- DOI
- Identifier
- Resource type
- Article
- Rights statement
- In Copyright
- License
- Attribution-NonCommercial-NoDerivs 4.0 International
- Journal title
- Open Forum Infectious Diseases
- Journal volume
- 9
- Journal issue
- 11
- Language
- English
- Version
- Publisher
- ISSN
- 2328-8957
- Publisher
- Oxford University Press
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