Stem cells and repair of lung injuries Public Deposited

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Creator
  • Randell, Scott
    • Affiliation: School of Medicine, Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center, Department of Medicine, Division of Pulmonary Diseases and Critical Care Medicine, Department of Cell Biology and Physiology
  • Neuringer, Isabel P
    • Affiliation: School of Medicine, Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center, Department of Medicine, Division of Pulmonary Diseases and Critical Care Medicine
Abstract
  • Abstract Fueled by the promise of regenerative medicine, currently there is unprecedented interest in stem cells. Furthermore, there have been revolutionary, but somewhat controversial, advances in our understanding of stem cell biology. Stem cells likely play key roles in the repair of diverse lung injuries. However, due to very low rates of cellular proliferation in vivo in the normal steady state, cellular and architectural complexity of the respiratory tract, and the lack of an intensive research effort, lung stem cells remain poorly understood compared to those in other major organ systems. In the present review, we concisely explore the conceptual framework of stem cell biology and recent advances pertinent to the lungs. We illustrate lung diseases in which manipulation of stem cells may be physiologically significant and highlight the challenges facing stem cell-related therapy in the lung.
Date of publication
Identifier
  • 15285789
  • doi:10.1186/1465-9921-5-6
Resource type
  • Article
Rights statement
  • In Copyright
Rights holder
  • Isabel P Neuringer et al.; licensee BioMed Central Ltd.
License
Journal title
  • Respiratory Research
Journal volume
  • 5
Journal issue
  • 1
Page start
  • 6
Language
  • English
Is the article or chapter peer-reviewed?
  • Yes
ISSN
  • 1465-9921
Bibliographic citation
  • Respiratory Research. 2004 Jul 20;5(1):6
Access
  • Open Access
Publisher
  • BioMed Central Ltd
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