Metabolomic Associations of Asthma in the Hispanic Community Health Study/Study of Latinos

Public Deposited
Analytics

Downloadable Content

Download PDF
Request Version for Screen Reader
Creator
  • Lee, Yura
    • Other Affiliation: University of Texas Health Science Center at Houston
  • Chen, Han
    • Other Affiliation: University of Texas Health Science Center at Houston
  • Chen, Wei
    • Other Affiliation: University of Pittsburgh
  • Qi, Qibin
    • Other Affiliation: Albert Einstein College of Medicine
  • Afshar, Majid
    • Other Affiliation: University of Wisconsin School of Medicine and Public Health
  • Cai, Jianwen
    • Gillings School of Global Public Health, Department of Biostatistics
  • Daviglus, Martha L.
    • Other Affiliation: University of Illinois College of Medicine
  • Thyagarajan, Bharat
    • Other Affiliation: University of Minnesota
  • North, Kari E.
    • Gillings School of Global Public Health, Department of Epidemiology
  • London, Stephanie J.
    • Other Affiliation: National Institutes of Health
  • Boerwinkle, Eric
    • Other Affiliation: University of Texas Health Science Center at Houston
  • Celedón, Juan C.
    • Other Affiliation: University of Pittsburgh
  • Kaplan, Robert C.
    • Other Affiliation: University of Wisconsin School of Medicine and Public Health
  • Yu, Bing
    • Other Affiliation: University of Texas Health Science Center at Houston
Abstract
  • Asthma disproportionally affects Hispanic and/or Latino backgrounds; however, the relation between circulating metabolites and asthma remains unclear. We conducted a cross-sectional study associating 640 individual serum metabolites, as well as twelve metabolite modules, with asthma in 3347 Hispanic/Latino background participants (514 asthmatics, 15.36%) from the Hispanic/Latino Community Health Study/Study of Latinos. Using survey logistic regression, per standard deviation (SD) increase in 1-arachidonoyl-GPA (20:4) was significantly associated with 32% high odds of asthma after accounting for clinical risk factors (p = 6.27 × 10−5), and per SD of the green module, constructed using weighted gene co-expression network, was suggestively associated with 25% high odds of asthma (p = 0.006). In the stratified analyses by sex and Hispanic and/or Latino backgrounds, the effect of 1-arachidonoyl-GPA (20:4) and the green module was predominantly observed in women (OR = 1.24 and 1.37, p < 0.001) and people of Cuban and Puerto-Rican backgrounds (OR = 1.25 and 1.27, p < 0.01). Mutations in Fatty Acid Desaturase 2 (FADS2) affected the levels of 1-arachidonoyl-GPA (20:4), and Mendelian Randomization analyses revealed that high genetically regulated 1-arachidonoyl-GPA (20:4) levels were associated with increased odds of asthma (p < 0.001). The findings reinforce a molecular basis for asthma etiology, and the potential causal effect of 1-arachidonoyl-GPA (20:4) on asthma provides an opportunity for future intervention.
Date of publication
Keyword
DOI
Identifier
Resource type
  • Article
Rights statement
  • In Copyright
License
  • Attribution 3.0 United States
Journal title
  • Metabolites
Journal volume
  • 12
Journal issue
  • 4
Page start
  • 359
Language
  • English
Version
  • Publisher
ISSN
  • 2218-1989

Relations

Parents:

This work has no parents.

In Collection:

Items

Thumbnail Title Date Uploaded Visibility Actions
file details metabolites-12-00359-v2.pdf 2022-05-03 Public Download