Limited educational attainment and radiographic and symptomatic knee osteoarthritis: a cross-sectional analysis using data from the Johnston County (North Carolina) Osteoarthritis Project Public Deposited

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  • Schwartz, Todd
    • Affiliation: Gillings School of Global Public Health, Department of Biostatistics
  • Jordan, Joanne
    • Affiliation: School of Medicine, Department of Orthopaedics, Thurston Arthritis Research Center
  • Callahan, Leigh
    • Affiliation: School of Medicine, Department of Orthopaedics, Department of Social Medicine, Thurston Arthritis Research Center
  • Shreffler, Jack
    • Affiliation: School of Medicine, Thurston Arthritis Research Center
  • Siaton, Bernadette C
    • Other Affiliation: Duke University Medical Center, DUMC 3918, Durham, NC 27710, USA
  • Renner, Jordan B
    • Affiliation: School of Medicine, Department of Radiology
  • Schoster, Britta
    • Affiliation: School of Medicine, Thurston Arthritis Research Center
  • Chen, Jiu-Chiuan
    • Other Affiliation: Division of Environmental Health, Keck School of Medicine of the University of Southern California, 1975 Zonal Avenue, KAM 500, Los Angeles, CA 90089- 9034, USA
  • Helmick, Charles G
    • Other Affiliation: Centers for Disease Control and Prevention, 1600 Clifton Rd, Atlanta, GA 30333, USA
  • Abstract Introduction Applying a cross-sectional analysis to a sample of 2,627 African-American and Caucasian adults aged ≥ 45 years from the Johnston County Osteoarthritis Project, we studied the association between educational attainment and prevalence of radiographic knee osteoarthritis and symptomatic knee osteoarthritis. Methods Age- and race-adjusted associations between education and osteoarthritis outcomes were assessed by gender-stratified logistic regression models, with additional models adjusting for body mass index, knee injury, smoking, alcohol use, and occupational factors. Results In an analysis of all participants, low educational attainment (<12 years) was associated with higher prevalence of four knee osteoarthritis outcomes (unilateral and bilateral radiographic and symptomatic osteoarthritis). Women with low educational attainment had 50% higher odds of having radiographic knee osteoarthritis and 65% higher odds of symptomatic knee osteoarthritis compared with those with higher educational attainment (≥ 12 years), by using fully adjusted models. In the subset of postmenopausal women, these associations tended to be weaker but little affected by adjustment for hormone replacement therapy. Men with low educational attainment had 85% higher odds of having symptomatic knee osteoarthritis by using fully adjusted models, but the association with radiographic knee osteoarthritis was explained by age. Conclusions After adjustment for known risk factors, educational attainment, as an indicator of socioeconomic status, is associated with symptomatic knee osteoarthritis in both men and women and with radiographic knee osteoarthritis in women.
Date of publication
  • doi:10.1186/ar2956
  • 20298606
Resource type
  • Article
Rights statement
  • In Copyright
Rights holder
  • Leigh F Callahan et al.; licensee BioMed Central Ltd.
Journal title
  • Arthritis Research & Therapy
Journal volume
  • 12
Journal issue
  • 2
Page start
  • R46
  • English
Is the article or chapter peer-reviewed?
  • Yes
  • 1478-6354
Bibliographic citation
  • Arthritis Research & Therapy. 2010 Mar 18;12(2):R46
  • Open Access
  • BioMed Central Ltd

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