ChIPOTle: a user-friendly tool for the analysis of ChIP-chip data Public Deposited

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Creator
  • Buck, Michael J
    • Affiliation: School of Medicine, Carolina Center for Genome Sciences
  • Lieb, Jason D.
    • Affiliation: School of Medicine, Carolina Center for Genome Sciences
  • Nobel, Andrew
    • Affiliation: College of Arts and Sciences, Department of Statistics and Operations Research
Abstract
  • Abstract ChIPOTle (Chromatin ImmunoPrecipitation On Tiled arrays) takes advantage of two unique properties of ChIP-chip data: the single-tailed nature of the data, caused by specific enrichment but not specific depletion of genomic fragments; and the predictable enrichment of DNA fragments adjacent to sites of direct protein-DNA interaction. Implemented as a Microsoft Excel macro written in Visual Basic, ChIPOTle uses a sliding window approach that yields improvements in the identification of bona fide sites of protein-DNA interaction.
Date of publication
DOI
Identifier
Resource type
  • Article
Rights statement
  • In Copyright
Rights holder
  • Michael J Buck et al.; licensee BioMed Central Ltd.
License
Journal title
  • Genome Biology
Journal volume
  • 6
Journal issue
  • 11
Page start
  • R97
Language
  • English
Is the article or chapter peer-reviewed?
  • Yes
ISSN
  • 1465-6906
Bibliographic citation
  • Genome Biology. 2005 Oct 19;6(11):R97
Access
  • Open Access
Publisher
  • BioMed Central Ltd
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