Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques
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Mercado, N.B, et al. Single-shot Ad26 Vaccine Protects Against Sars-cov-2 In Rhesus Macaques. 2020. https://doi.org/10.17615/80t4-de97APA
Mercado, N., Zahn, R., Wegmann, F., Loos, C., Chandrashekar, A., Yu, J., Liu, J., Peter, L., Mc Mahan, K., Tostanoski, L., He, X., Martinez, D., Rutten, L., Bos, R., Van Manen, D., Vellinga, J., Custers, J., Langedijk, J., Kwaks, T., Bakkers, M., Zuijdgeest, D., Rosendahl Huber, S., Atyeo, C., Fischinger, S., Burke, J., Feldman, J., Hauser, B., Caradonna, T., Bondzie, E., Dagotto, G., Gebre, M., Hoffman, E., Jacob Dolan, C., Kirilova, M., Li, Z., Lin, Z., Mahrokhian, S., Maxfield, L., Nampanya, F., Nityanandam, R., Nkolola, J., Patel, S., Ventura, J., Verrington, K., Wan, H., Pessaint, L., Van Ry, A., Blade, K., Strasbaugh, A., Cabus, M., Brown, R., Cook, A., Zouantchangadou, S., Teow, E., Andersen, H., Lewis, M., Cai, Y., Chen, B., Schmidt, A., Reeves, R., Baric, R., Lauffenburger, D., Alter, G., Stoffels, P., Mammen, M., Van Hoof, J., Schuitemaker, H., & Barouch, D. (2020). Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques. https://doi.org/10.17615/80t4-de97Chicago
Mercado, N.B., R Zahn, F Wegmann, C Loos, A Chandrashekar, J Yu, J Liu et al. 2020. Single-Shot Ad26 Vaccine Protects Against Sars-Cov-2 In Rhesus Macaques. https://doi.org/10.17615/80t4-de97- Creator
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Mercado, N.B.
- Other Affiliation: Harvard Medical School
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Zahn, R.
- Other Affiliation: Janssen Vaccines and Prevention BV
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Wegmann, F.
- Other Affiliation: Janssen Vaccines and Prevention BV
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Loos, C.
- Other Affiliation: Massachusetts Institute of Technology
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Chandrashekar, A.
- Other Affiliation: Harvard Medical School
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Yu, J.
- Other Affiliation: Harvard Medical School
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Liu, J.
- Other Affiliation: Harvard Medical School
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Peter, L.
- Other Affiliation: Harvard Medical School
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McMahan, K.
- Other Affiliation: Harvard Medical School
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Tostanoski, L.H.
- Other Affiliation: Harvard Medical School
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He, X.
- Other Affiliation: Harvard Medical School
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Martinez, D.R.
- Affiliation: University of North Carolina at Chapel Hill
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Rutten, L.
- Other Affiliation: Janssen Vaccines and Prevention BV
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Bos, R.
- Other Affiliation: Janssen Vaccines and Prevention BV
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van Manen, D.
- Other Affiliation: Janssen Vaccines and Prevention BV
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Vellinga, J.
- Other Affiliation: Janssen Vaccines and Prevention BV
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Custers, J.
- Other Affiliation: Janssen Vaccines and Prevention BV
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Langedijk, J.P.
- Other Affiliation: Janssen Vaccines and Prevention BV
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Kwaks, T.
- Other Affiliation: Janssen Vaccines and Prevention BV
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Bakkers, M.J.G.
- Other Affiliation: Janssen Vaccines and Prevention BV
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Zuijdgeest, D.
- Other Affiliation: Janssen Vaccines and Prevention BV
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Rosendahl Huber, S.K.
- Other Affiliation: Janssen Vaccines and Prevention BV
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Atyeo, C.
- Other Affiliation: Harvard Medical School
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Fischinger, S.
- Other Affiliation: Harvard Medical School
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Burke, J.S.
- Other Affiliation: Harvard Medical School
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Feldman, J.
- Other Affiliation: Harvard Medical School
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Hauser, B.M.
- Other Affiliation: Harvard Medical School
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Caradonna, T.M.
- Other Affiliation: Harvard Medical School
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Bondzie, E.A.
- Other Affiliation: Harvard Medical School
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Dagotto, G.
- Other Affiliation: Harvard Medical School
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Gebre, M.S.
- Other Affiliation: Harvard Medical School
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Hoffman, E.
- Other Affiliation: Harvard Medical School
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Jacob-Dolan, C.
- Other Affiliation: Harvard Medical School
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Kirilova, M.
- Other Affiliation: Harvard Medical School
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Li, Z.
- Other Affiliation: Harvard Medical School
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Lin, Z.
- Other Affiliation: Harvard Medical School
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Mahrokhian, S.H.
- Other Affiliation: Harvard Medical School
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Maxfield, L.F.
- Other Affiliation: Harvard Medical School
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Nampanya, F.
- Other Affiliation: Harvard Medical School
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Nityanandam, R.
- Other Affiliation: Harvard Medical School
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Nkolola, J.P.
- Other Affiliation: Harvard Medical School
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Patel, S.
- Other Affiliation: Harvard Medical School
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Ventura, J.D.
- Other Affiliation: Harvard Medical School
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Verrington, K.
- Other Affiliation: Harvard Medical School
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Wan, H.
- Other Affiliation: Harvard Medical School
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Pessaint, L.
- Other Affiliation: Bioqual
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Van Ry, A.
- Other Affiliation: Bioqual
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Blade, K.
- Other Affiliation: Bioqual
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Strasbaugh, A.
- Other Affiliation: Bioqual
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Cabus, M.
- Other Affiliation: Bioqual
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Brown, R.
- Other Affiliation: Bioqual
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Cook, A.
- Other Affiliation: Bioqual
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Zouantchangadou, S.
- Other Affiliation: Bioqual
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Teow, E.
- Other Affiliation: Bioqual
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Andersen, H.
- Other Affiliation: Bioqual
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Lewis, M.G.
- Other Affiliation: Bioqual
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Cai, Y.
- Other Affiliation: Children's Hospital, Boston
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Chen, B.
- Other Affiliation: Massachusetts Consortium on Pathogen Readiness
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Schmidt, A.G.
- Other Affiliation: Harvard Medical School
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Reeves, R.K.
- Other Affiliation: Harvard Medical School
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Baric, R.S.
- Affiliation: University of North Carolina at Chapel Hill
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Lauffenburger, D.A.
- Other Affiliation: Massachusetts Institute of Technology
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Alter, G.
- Other Affiliation: Massachusetts Consortium on Pathogen Readiness
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Stoffels, P.
- Other Affiliation: Janssen Vaccines and Prevention BV
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Mammen, M.
- Other Affiliation: Janssen Vaccines and Prevention BV
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Van Hoof, J.
- Other Affiliation: Janssen Vaccines and Prevention BV
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Schuitemaker, H.
- Other Affiliation: Janssen Vaccines and Prevention BV
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Barouch, D.H.
- Other Affiliation: Harvard Medical School
- Abstract
- A safe and effective vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may be required to end the coronavirus disease 2019 (COVID-19) pandemic1–8. For global deployment and pandemic control, a vaccine that requires only a single immunization would be optimal. Here we show the immunogenicity and protective efficacy of a single dose of adenovirus serotype 26 (Ad26) vector-based vaccines expressing the SARS-CoV-2 spike (S) protein in non-human primates. Fifty-two rhesus macaques (Macaca mulatta) were immunized with Ad26 vectors that encoded S variants or sham control, and then challenged with SARS-CoV-2 by the intranasal and intratracheal routes9,10. The optimal Ad26 vaccine induced robust neutralizing antibody responses and provided complete or near-complete protection in bronchoalveolar lavage and nasal swabs after SARS-CoV-2 challenge. Titres of vaccine-elicited neutralizing antibodies correlated with protective efficacy, suggesting an immune correlate of protection. These data demonstrate robust single-shot vaccine protection against SARS-CoV-2 in non-human primates. The optimal Ad26 vector-based vaccine for SARS-CoV-2, termed Ad26.COV2.S, is currently being evaluated in clinical trials.
- Date of publication
- 2020
- Keyword
- DOI
- Identifier
- Resource type
- Article
- Rights statement
- In Copyright
- Journal title
- Nature
- Journal volume
- 586
- Journal issue
- 7830
- Page start
- 583
- Page end
- 588
- ISSN
- 1476-4687
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