Number of prior live births is associated with higher arterial stiffness but not its change in older women: the atherosclerosis risk in communities study

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  • Bonner, Alison N.
    • Affiliation: School of Medicine
  • Jayawickreme, Shantal
    • Affiliation: School of Medicine
  • Malek, Angela M.
    • Other Affiliation: Medical University of South Carolina
  • Vladutiu, Catherine J.
    • Affiliation: School of Medicine, Department of Obstetrics and Gynecology
  • Oliver-Williams, Clare
    • Other Affiliation: University of Leicester
  • Cortés, Yamnia I.
    • Affiliation: School of Nursing
  • Tanaka, Hirofumi
    • Other Affiliation: University of Texas at Austin
  • Meyer, Michelle L.
    • Affiliation: School of Medicine, Department of Emergency Medicine
Abstract
  • Introduction Although studies have demonstrated a J-shaped association between parity and cardiovascular disease (CVD), the association with arterial stiffness is not fully understood. Methods We examined the association between parity and carotid-femoral pulse wave velocity (cfPWV), a measure of central arterial stiffness. We conducted a longitudinal analysis of 1220 women (mean age 73.7 years) who attended the Atherosclerosis Risk in Communities Study visit 5 (2011-2013). At visit 2 (1990-1992), women self-reported parity (number of prior live births), which we categorized as: 0 (never pregnant or pregnant with no live births); 1-2 (referent); 3-4; and 5+ live births. Technicians measured cfPWV at visit 5 (2011-2013) and visit 6 or 7 (2016-2019). Multivariable linear regression modeled the associations of parity with visit 5 cfPWV and cfPWV change between visit 5 and 6/7 adjusted for demographics and potential confounding factors. Results Participants reported 0 (7.7%), 1-2 (38.7%), 3-4 (40.0%), or 5+ (13.6%) prior live births. In adjusted analyses, women with 5+ live births had a higher visit 5 cfPWV (β=50.6 cm/s, 95% confidence interval: 3.6, 97.7 cm/s) than those with 1-2 live births. No statistically significant associations were observed for other parity groups with visit 5 cfPWV or with cfPWV change. Discussion In later life, women with 5+ live births had higher arterial stiffness than those with 1-2 live births, but cfPWV change did not differ by parity, suggesting women with 5+ live births should be targeted for early primary prevention of CVD given their higher arterial stiffness at later-life.
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  • Article
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  • In Copyright
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  • Attribution 4.0 International
Journal title
  • Frontiers in Cardiovascular Medicine
Journal volume
  • 10
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  • English
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  • 2297-055X
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  • Frontiers Media

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