Herbal Remedies for Constipation-Predominant Irritable Bowel Syndrome: A Systematic Review of Randomized Controlled Trials

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  • Chiarioni, Giuseppe
    • Affiliation: School of Medicine, Department of Medicine, Division of Gastroenterology and Hepatology
  • Popa, Stefan Lucian
    • Other Affiliation: “Iuliu Hatieganu” University of Medicine and Pharmacy
  • Ismaiel, Abdulrahman
    • Other Affiliation: “Iuliu Hatieganu” University of Medicine and Pharmacy
  • Pop, Cristina
    • Other Affiliation: “Iuliu Hatieganu” University of Medicine and Pharmacy
  • Dumitrascu, Dinu Iuliu
    • Other Affiliation: “Iuliu Hatieganu” University of Medicine and Pharmacy
  • Brata, Vlad Dumitru
    • Other Affiliation: “Iuliu Hatieganu” University of Medicine and Pharmacy
  • Duse, Traian Adrian
    • Other Affiliation: “Iuliu Hatieganu” University of Medicine and Pharmacy
  • Incze, Victor
    • Other Affiliation: “Iuliu Hatieganu” University of Medicine and Pharmacy
  • Surdea-Blaga, Teodora
    • Other Affiliation: “Iuliu Hatieganu” University of Medicine and Pharmacy
Abstract
  • Background: Constipation-predominant irritable bowel syndrome (IBS-C) is a common gastrointestinal disorder characterized by abdominal pain and altered bowel habits. Conventional treatments for IBS-C often provide limited efficiency, leading to an increasing interest in exploring herbal remedies. This systematic review aims to evaluate the efficacy and safety of herbal remedies in the management of IBS-C. Materials and Methods: A comprehensive search of PubMed, MEDLINE, Embase, Scopus, and the Cochrane Library was conducted to identify relevant studies published up to July 2023 and data extraction was performed independently by two reviewers. Results: Overall, the included studies demonstrated some evidence of the beneficial effects of herbal remedies on IBS-C symptoms, including improvements in bowel frequency, stool consistency, abdominal pain, and quality of life. However, the heterogeneity of the interventions and outcome measures limited the ability to perform a meta-analysis. Conclusion: This systematic review suggests that herbal remedies may have potential benefits in the management of IBS-C. However, the quality of evidence is limited, and further well-designed, large-scale RCTs are needed to establish the efficacy and safety of specific herbal remedies for IBS-C. Clinicians should exercise caution when recommending herbal remedies and consider individual patient characteristics and preferences.
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  • Article
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  • Attribution 4.0 International
Journal title
  • Nutrients
Journal volume
  • 15
Journal issue
  • 19
Page start
  • 4216
Language
  • English
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  • Publisher
ISSN
  • 2072-6643
Publisher
  • MDPI

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