A description of the methods of the aspirin supplementation for pregnancy indicated risk reduction in nulliparas (ASPIRIN) study
Public DepositedAdd to collection
You do not have access to any existing collections. You may create a new collection.
Downloadable Content
Download PDFCitation
MLA
Hoffman, Matthew K, et al. A Description of the Methods of the Aspirin Supplementation for Pregnancy Indicated Risk Reduction In Nulliparas (aspirin) Study. BioMed Central, 2017. https://doi.org/10.17615/qgxp-se67APA
Hoffman, M., Goudar, S., Kodkany, B., Goco, N., Koso Thomas, M., Miodovnik, M., Mc Clure, E., Wallace, D., Hemingway Foday, J., Tshefu, A., Lokangaka, A., Bose, C., Chomba, E., Mwenechanya, M., Carlo, W., Garces, A., Krebs, N., Hambidge, K., Saleem, S., Goldenberg, R., Patel, A., Hibberd, P., Esamai, F., Liechty, E., Silver, R., & Derman, R. (2017). A description of the methods of the aspirin supplementation for pregnancy indicated risk reduction in nulliparas (ASPIRIN) study. BioMed Central. https://doi.org/10.17615/qgxp-se67Chicago
Hoffman, Matthew K., Shivaprasad S Goudar, Bhalachandra S Kodkany, Norman Goco, Marion Koso Thomas, Menachem Miodovnik, Elizabeth M Mc Clure et al. 2017. A Description of the Methods of the Aspirin Supplementation for Pregnancy Indicated Risk Reduction In Nulliparas (aspirin) Study. BioMed Central. https://doi.org/10.17615/qgxp-se67- Creator
-
Hoffman, Matthew K.
- Other Affiliation: Christiana Care, Newark, DE, USA
-
Goudar, Shivaprasad S.
- Other Affiliation: KLE’s JN Medical College, Belgaum, India
-
Kodkany, Bhalachandra S.
- Other Affiliation: KLE’s JN Medical College, Belgaum, India
-
Goco, Norman
- Other Affiliation: RTI International, 3040 E. Cornwallis Road, Research Triangle Park, NC, USA
-
Koso-Thomas, Marion
- Other Affiliation: Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA
-
Miodovnik, Menachem
- Other Affiliation: Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA
-
McClure, Elizabeth M.
- Other Affiliation: RTI International, 3040 E. Cornwallis Road, Research Triangle Park, NC, USA
-
Wallace, Dennis D.
- Other Affiliation: RTI International, 3040 E. Cornwallis Road, Research Triangle Park, NC, USA
-
Hemingway-Foday, Jennifer J.
- Other Affiliation: RTI International, 3040 E. Cornwallis Road, Research Triangle Park, NC, USA
-
Tshefu, Antoinette
- Other Affiliation: Kinshasa School of Public Health, Kinshasa, Democratic Republic of the Congo
-
Lokangaka, Adrien
- Other Affiliation: Kinshasa School of Public Health, Kinshasa, Democratic Republic of the Congo
-
Bose, Carl
- Affiliation: School of Medicine, Department of Pediatrics
-
Chomba, Elwyn
- Other Affiliation: University Teaching Hospital, Lusaka, Zambia
-
Mwenechanya, Musaku
- Other Affiliation: University Teaching Hospital, Lusaka, Zambia
-
Carlo, Waldemar A.
- Other Affiliation: University of Alabama at Birmingham, Birmingham, AL, USA
-
Garces, Ana
- Other Affiliation: Instituto de Nutrición de Centroamérica y Panamá (INCAP), Guatemala City, Guatemala
-
Krebs, Nancy F.
- Other Affiliation: University of Colorado School of Medicine, Denver, CO, USA
-
Hambidge, K. M.
- Other Affiliation: University of Colorado School of Medicine, Denver, CO, USA
-
Saleem, Sarah
- Other Affiliation: Aga Khan University, Karachi, Pakistan
-
Goldenberg, Robert L.
- Other Affiliation: Columbia University, New York, NY, USA
-
Patel, Archana
- Other Affiliation: Lata Medical Research Foundation, Nagpur, India
-
Hibberd, Patricia L.
- Other Affiliation: Boston University School of Public Health, Boston, MA, USA
-
Esamai, Fabian
- Other Affiliation: Department of Child Health and Paediatrics, Moi University School of Medicine, Eldoret, Kenya
-
Liechty, Edward A.
- Other Affiliation: School of Medicine, Indiana University, Indianapolis, IN, USA
-
Silver, Robert
- Other Affiliation: University of Utah, Salt Lake City, UT, USA
-
Derman, Richard J.
- Other Affiliation: Thomas Jefferson University, Philadelphia, PA, USA
- Abstract
- Background Preterm birth (PTB) remains the leading cause of neonatal mortality and long term disability throughout the world. Though complex in its origins, a growing body of evidence suggests that first trimester administration of low dose aspirin (LDA) may substantially reduce the rate of PTB. Methods Hypothesis: LDA initiated in the first trimester reduces the risk of preterm birth. Study Design Type: Prospective randomized, placebo-controlled, double-blinded multi-national clinical trial conducted in seven low and middle income countries. Trial will be individually randomized with one-to-one ratio (intervention/control) Population: Nulliparous women between the ages of 14 and 40, with a singleton pregnancy between 6 0/7 weeks and 13 6/7 weeks gestational age (GA) confirmed by ultrasound prior to enrollment, no more than two previous first trimester pregnancy losses, and no contraindications to aspirin. Intervention: Daily administration of low dose (81 mg) aspirin, initiated between 6 0/7 weeks and 13 6/7 weeks GA and continued to 36 0/7 weeks GA, compared to an identical appearing placebo. Compliance and outcomes will be assessed biweekly. Outcomes Primary outcome: Incidence of PTB (birth prior to 37 0/7 weeks GA). Secondary outcomes Incidence of preeclampsia/eclampsia, small for gestational age and perinatal mortality. Discussion This study is unique as it will examine the impact of LDA early in pregnancy in low-middle income countries with preterm birth as a primary outcome. The importance of developing low-cost, high impact interventions in low-middle income countries is magnified as they are often unable to bear the financial costs of treating illness. Trial registration ClinicalTrials.gov identifier: NCT02409680 Date: March 30, 2015
- Date of publication
- May 3, 2017
- DOI
- Identifier
- Resource type
- Article
- Rights statement
- In Copyright
- Rights holder
- The Author(s).
- Journal title
- BMC Pregnancy and Childbirth
- Journal volume
- 17
- Journal issue
- 1
- Page start
- 135
- Language
- English
- Bibliographic citation
- BMC Pregnancy and Childbirth. 2017 May 03;17(1):135
- Publisher
- BioMed Central
Relations
- Parents:
This work has no parents.
Items
Thumbnail | Title | Date Uploaded | Visibility | Actions |
---|---|---|---|---|
12884_2017_article_1312.pdf | 2019-05-07 | Public | Download |