Allergist-Reported Trends in the Practice of Food Allergen Oral Immunotherapy Public Deposited
- Creator
-
Greenhawt, Matthew J.
- Other Affiliation: University of Michigan, Ann Arbor
-
Vickery, Brian P.
- Affiliation: University of North Carolina at Chapel Hill
- Abstract
- Food allergen oral immunotherapy (OIT) is an experimental, immune-modifying therapy that may induce clinical desensitization in some patients. OIT is still in early phase clinical research, but some provider may offer OIT as a clinical service. To understand the current practices of allergists performing OIT an on-line survey was emailed to members of the American Academy of Allergy Asthma and Immunology. Among 442 respondents, 61 (13.8%) reported participating in OIT, including 28 in non-academic settings. Informed consent for OIT was obtained by 91.3%, IRB approval by 47.7% and Investigational New Drug (IND) approval by 38.1%. Compared to non-academic participants, more academic participants used peanut OIT, obtained IRB and IND (p <0.0001 respectively), and challenged patients prior to entry (p=0.008). More non-academic providers billed the patient or insurance for reimbursement (p<0.0001). Low reported regard for the importance for FDA approval or a standardized product (increased odds), and high regard for better safety data (decreased odds) were associated with considering to offer OIT as a service. Significant differences exist in OIT occurring in academic vs. non-academic settings. Further assessment is needed regarding the different motivations and practice styles among providers offering OIT, and those considering doing so.
- Date of publication
- 2015
- Keyword
- CPT
- Investigational New Drug
- American Academy of Allergy
- Odds ratio
- Institutional review board
- AAAAI
- Provider attitudes
- Food oral immunotherapy
- OR
- Current Procedural Terminology
- IRB
- Food allergy
- OIT
- FDA
- Oral immunotherapy
- Asthma & Immunology
- Clinical trial
- IND
- US Food and Drug Administration
- Sublingual immunotherapy
- Oral food challenge
- DOI
- Identifier
- PMCID: PMC4291536
- Publisher DOI: https://doi.org/10.1016/j.jaip.2014.06.023
- Onescience id: a6d5e4a4cf2b99dfe652fc1d028423634c28cf90
- PMID: 25577615
- Resource type
- Article
- Rights statement
- In Copyright
- Journal title
- The Journal of Allergy and Clinical Immunology - in Practice
- Journal volume
- 3
- Journal issue
- 1
- Page start
- 33
- Page end
- 38
- Language
- English
- ISSN
- 2213-2198
- 2213-2201
- Parents:
This work has no parents.
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