Escape from Human Monoclonal Antibody Neutralization Affects In Vitro and In Vivo Fitness of Severe Acute Respiratory Syndrome Coronavirus

Public Deposited
Analytics

Downloadable Content

Download PDF
Request Version for Screen Reader
Creator
  • Rockx, Barry
    • Affiliation: Gillings School of Global Public Health, Department of Epidemiology
  • Donaldson, Eric
    • Affiliation: Gillings School of Global Public Health, Department of Epidemiology
  • Frieman, Matthew
    • Affiliation: Gillings School of Global Public Health, Department of Epidemiology
  • Sheahan, Timothy
    • Affiliation: Gillings School of Global Public Health, Department of Epidemiology
  • Corti, Davide
    • Other Affiliation: Institute for Research in Biomedicine
  • Lanzavecchia, Antonio
    • Other Affiliation: Institute for Research in Biomedicine
  • Baric, Ralph S.
    • Affiliation: Gillings School of Global Public Health, Department of Epidemiology
Abstract
  • Severe Acute Respiratory Syndrome (SARS) emerged as a human disease in 2002 and detailed phylogenetic analysis and epidemiological studies have suggested that the SARS-Coronavirus (SARS-CoV) originated from animals. The Spike (S) glycoprotein has been identified as a major target of protective immunity and contains at least three regions that are targeted by neutralizing antibodies in the S1 and S2 domains. We previously characterized a panel of neutralizing human monoclonal antibodies (MAbs) but the majority of epitopes recognized by the MAbs remained unknown.
Date of publication
Keyword
DOI
Identifier
Resource type
  • Article
Rights statement
  • In Copyright
Journal title
  • The Journal of Infectious Diseases
Journal volume
  • 201
Journal issue
  • 6
Page start
  • 946
Page end
  • 955
Language
  • English
ISSN
  • 0022-1899

Relations

Parents:

This work has no parents.

Items

Thumbnail Title Date Uploaded Visibility Actions
file details nihms-167090.pdf 2020-04-03 Public Download