Preliminary Acceptability of a Home-Based Peripheral Blood Collection Device for Viral Load Testing in the Context of Analytical Treatment Interruptions in HIV Cure Trials: Results from a Nationwide Survey in the United States
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Dubé, Karine, et al. Preliminary Acceptability of a Home-based Peripheral Blood Collection Device for Viral Load Testing In the Context of Analytical Treatment Interruptions In Hiv Cure Trials: Results From a Nationwide Survey In the United States. 2022. https://doi.org/10.17615/v7jr-1420APA
Dubé, K., Eskaf, S., Hastie, E., Agarwal, H., Henley, L., Roebuck, C., Carter, W., Dee, L., Taylor, J., Mapp, D., Campbell, D., Villa, T., Peterson, B., Lynn, K., Lalley Chareczko, L., Hiserodt, E., Kim, S., Rosenbloom, D., Evans, B., Anderson, M., Hazuda, D., Shipley, L., Bateman, K., Howell, B., Mounzer, K., Tebas, P., & Montaner, L. (2022). Preliminary Acceptability of a Home-Based Peripheral Blood Collection Device for Viral Load Testing in the Context of Analytical Treatment Interruptions in HIV Cure Trials: Results from a Nationwide Survey in the United States. https://doi.org/10.17615/v7jr-1420Chicago
Dubé, Karine, Shadi Eskaf, Elizabeth Hastie, Harsh Agarwal, Laney Henley, Christopher Roebuck, William B Carter et al. 2022. Preliminary Acceptability of a Home-Based Peripheral Blood Collection Device for Viral Load Testing In the Context of Analytical Treatment Interruptions In Hiv Cure Trials: Results From a Nationwide Survey In the United States. https://doi.org/10.17615/v7jr-1420- Creator
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Dubé, Karine
- Affiliation: Gillings School of Global Public Health
- Eskaf, Shadi
- Hastie, Elizabeth
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Agarwal, Harsh
- Affiliation: Gillings School of Global Public Health
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Henley, Laney
- Affiliation: Gillings School of Global Public Health
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Roebuck, Christopher
- Other Affiliation: Cornell University
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Carter, William B.
- Other Affiliation: Martin Delaney BEAT-HIV Collaboratory Community Advisory Board
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Dee, Lynda
- Other Affiliation: AIDS Action Baltimore
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Taylor, Jeff
- Other Affiliation: Delaney AIDS Research Enterprise (DARE) Community Advisory Board
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Mapp, Derrick
- Other Affiliation: AIDS Treatment Activists Coalition
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Campbell, Danielle M.
- Other Affiliation: AIDS Treatment Activists Coalition
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Villa, Thomas J.
- Other Affiliation: HOPE Martin Delaney Collaboratory
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Peterson, Beth
- Other Affiliation: Wistar Institute
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Lynn, Kenneth M.
- Other Affiliation: Hospital of the University of Pennsylvania
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Lalley-Chareczko, Linden
- Other Affiliation: Philadelphia FIGHT Community Health Centers
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Hiserodt, Emily
- Other Affiliation: Philadelphia FIGHT Community Health Centers
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Kim, Sukyung
- Other Affiliation: Hospital of the University of Pennsylvania
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Rosenbloom, Daniel
- Other Affiliation: Merck & Co, Inc.
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Evans, Brad R.
- Other Affiliation: Merck & Co, Inc.
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Anderson, Melanie
- Other Affiliation: Merck & Co, Inc.
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Hazuda, Daria J.
- Other Affiliation: Merck & Co, Inc.
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Shipley, Lisa
- Other Affiliation: Merck & Co, Inc.
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Bateman, Kevin
- Other Affiliation: Merck & Co, Inc.
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Howell, Bonnie J.
- Other Affiliation: Merck & Co, Inc.
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Mounzer, Karam
- Other Affiliation: Hospital of the University of Pennsylvania
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Tebas, Pablo
- Other Affiliation: Hospital of the University of Pennsylvania
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Montaner, Luis J.
- Other Affiliation: Wistar Institute
- Abstract
- Frequent viral load testing is necessary during analytical treatment interruptions (ATIs) in HIV cure-directed clinical trials, though such may be burdensome and inconvenient to trial participants. We implemented a national, cross-sectional survey in the United States to examine the acceptability of a novel home-based peripheral blood collection device for HIV viral load testing. Between June and August 2021, we distributed an online survey to people with HIV (PWH) and community members, biomedical HIV cure researchers and HIV care providers. We performed descriptive analyses to summarize the results. We received 73 survey responses, with 51 from community members, 12 from biomedical HIV cure researchers and 10 from HIV care providers. Of those, 51 (70%) were cisgender men and 50 (68%) reported living with HIV. Most (>80% overall) indicated that the device would be helpful during ATI trials and they would feel comfortable using it themselves or recommending it to their patients/participants. Of the 50 PWH, 42 (84%) indicated they would use the device if they were participating in an ATI trial and 27 (54%) also expressed a willingness to use the device outside of HIV cure studies. Increasing sensitivity of viral load tests and pluri-potency of the device (CD4 count, chemistries) would augment acceptability. Survey findings provide evidence that viral load home testing would be an important adjunct to ongoing HIV cure-directed trials involving ATIs. Survey findings may help inform successful implementation and uptake of the device in the context of personalized HIV care.
- Date of publication
- 2022
- Keyword
- DOI
- Identifier
- Resource type
- Article
- Rights statement
- In Copyright
- License
- Attribution 3.0 United States
- Journal title
- Journal of Personalized Medicine
- Journal volume
- 12
- Journal issue
- 2
- Page start
- 231
- Language
- English
- Version
- Publisher
- ISSN
- 2075-4426
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