Design of the Prevention of Adult Caries Study (PACS): a randomized clinical trial assessing the effect of a chlorhexidine dental coating for the prevention of adult caries Public Deposited

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Creator
  • White, B Alexander
    • Other Affiliation: DentaQuest Institute, 2400 Computer Dr, Westborough MA 01581, USA
  • Laws, Reesa L
    • Other Affiliation: Center for Health Research, 3800 N. Interstate Blvd, Portland, Oregon 97227, USA
  • Snyder, John J
    • Other Affiliation: Permanente Dental Associates, 500 NE Multnomah St, Suite 100, Portland OR 97232, USA
  • Papas, Athena S
    • Other Affiliation: Tufts University School of Dental Medicine, 1 Kneeland St., Boston, MA 02111, USA
  • Hollis, Jack F
    • Other Affiliation: Center for Health Research, 3800 N. Interstate Blvd, Portland, Oregon 97227, USA
  • Gullion, Christina M
    • Other Affiliation: Center for Health Research, 3800 N. Interstate Blvd, Portland, Oregon 97227, USA
  • Vollmer, William M
    • Other Affiliation: Center for Health Research, 3800 N. Interstate Blvd, Portland, Oregon 97227, USA
  • Bader, James D
    • Affiliation: School of Dentistry, Department of Operative Dentistry
  • Fellows, Jeffrey L
    • Other Affiliation: Center for Health Research, 3800 N. Interstate Blvd, Portland, Oregon 97227, USA
  • Maupomé, Gerardo
    • Other Affiliation: Indiana University School of Dentistry, 415 Lansing St., Indianapolis IN 46202, USA
Abstract
  • Abstract Background Dental caries is one of the primary causes of tooth loss among adults. It is estimated to affect a majority of Americans aged 55 and older, with a disproportionately higher burden in disadvantaged populations. Although a number of treatments are currently in use for caries prevention in adults, evidence for their efficacy and effectiveness is limited. Methods/Design The Prevention of Adult Caries Study (PACS) is a multicenter, placebo-controlled, double-blind, randomized clinical trial of the efficacy of a chlorhexidine (10% w/v) dental coating in preventing adult caries. Participants (n = 983) were recruited from four different dental delivery systems serving four diverse communities, including one American Indian population, and were randomized to receive either chlorhexidine or a placebo treatment. The primary outcome is the net caries increment (including non-cavitated lesions) from baseline to 13 months of follow-up. A cost-effectiveness analysis also will be considered. Discussion This new dental treatment, if efficacious and approved for use by the Food and Drug Administration (FDA), would become a new in-office, anti-microbial agent for the prevention of adult caries in the United States. Trial Registration Number NCT00357877
Date of publication
Identifier
  • doi:10.1186/1472-6831-10-23
  • 20923557
Resource type
  • Article
Rights statement
  • In Copyright
Rights holder
  • William M Vollmer et al.; licensee BioMed Central Ltd.
License
Journal title
  • BMC Oral Health
Journal volume
  • 10
Journal issue
  • 1
Page start
  • 23
Language
  • English
Is the article or chapter peer-reviewed?
  • Yes
ISSN
  • 1472-6831
Bibliographic citation
  • BMC Oral Health. 2010 Oct 05;10(1):23
Access
  • Open Access
Publisher
  • BioMed Central Ltd
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