Genomic regions associated with susceptibility to Barrett’s esophagus and esophageal adenocarcinoma in African Americans: The cross BETRNet admixture study

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  • Sun, Xiangqing
    • Other Affiliation: Department of Population and Quantitative Health Sciences; Case Western Reserve University
  • Chandar, Apoorva K.
    • Other Affiliation: Division of Gastroenterology and Hepatology; University Hospitals Cleveland Medical Center; Case Western Reserve University School of Medicine
  • Canto, Marcia I.
    • Other Affiliation: Division of Gastroenterology and Hepatology; Johns Hopkins Medical Institutions
  • Thota, Prashanthi N.
    • Other Affiliation: Department of Gastroenterology and Hepatology; Cleveland Clinic
  • Brock, Malcom
    • Other Affiliation: Department of Cardiology and Thoracic Surgery; Johns Hopkins Medical Institutions
  • Shaheen, Nicholas J.
    • Affiliation: School of Medicine
  • Beer, David G.
    • Other Affiliation: Thoracic Surgery; Department of Surgery; University of Michigan
  • Wang, Jean S.
    • Other Affiliation: Division of Gastroenterology; Washington University School of Medicine
  • Falk, Gary W.
    • Other Affiliation: University of Pennsylvania Perelman School of Medicine
  • Iyer, Prasad G.
    • Other Affiliation: Division of Gastroenterology and Hepatology; Mayo Clinic
  • Abrams, Julian A.
    • Other Affiliation: Department of Medicine; Columbia University Medical Center
  • Venkat-Ramani, Medha
    • Other Affiliation: Division of Gastroenterology and Hepatology; University Hospitals Cleveland Medical Center; Case Western Reserve University School of Medicine
  • Veigl, Martina
    • Other Affiliation: Division of General Medical Sciences (Oncology); Case Comprehensive Cancer Center; Case Western Reserve University School of Medicine
  • Miron, Alexander
    • Other Affiliation: Department of Genetics and Genome Sciences; Case Western Reserve University School of Medicine
  • Willis, Joseph
    • Other Affiliation: Department of Pathology; University Hospitals Case Medical Center; Case Western Reserve University School of Medicine
  • Patil, Deepa T.
    • Other Affiliation: Department of Pathology; Cleveland Clinic
  • Nalbantoglu, Ilke
    • Other Affiliation: Department of Pathology and Immunology; Washington University School of Medicine
  • Guda, Kishore
    • Other Affiliation: Division of General Medical Sciences (Oncology); Case Comprehensive Cancer Center; Case Western Reserve University School of Medicine
  • Markowitz, Sanford D.
    • Other Affiliation: Division of Oncology and Case Comprehensive Cancer Center; Case Western Reserve University School of Medicine
  • Zhu, Xiaofeng
    • Other Affiliation: Department of Population and Quantitative Health Sciences; Case Western Reserve University
  • Elston, Robert
    • Other Affiliation: Department of Population and Quantitative Health Sciences; Case Western Reserve University
  • Chak, Amitabh
    • Other Affiliation: Division of General Medical Sciences (Oncology); Case Comprehensive Cancer Center; Case Western Reserve University School of Medicine
Abstract
  • Barrett’s esophagus (BE) and esophageal adenocarcinoma (EAC) are far more prevalent in European Americans than in African Americans. Hypothesizing that this racial disparity in prevalence might represent a genetic susceptibility, we used an admixture mapping approach to interrogate disease association with genomic differences between European and African ancestry.
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  • Article
Rights statement
  • In Copyright
Journal title
  • PloS One
Journal volume
  • 12
Journal issue
  • 10
Page start
  • e0184962
Language
  • English
ISSN
  • 1932-6203

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