Scheduled Intermittent Screening with Rapid Diagnostic Tests and Treatment with Dihydroartemisinin-Piperaquine versus Intermittent Preventive Therapy with Sulfadoxine-Pyrimethamine for Malaria in Pregnancy in Malawi: An Open-Label Randomized Controlled Trial

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  • Madanitsa, Mwayiwawo
    • Other Affiliation: Department of Clinical Sciences; Liverpool School of Tropical Medicine
  • Kalilani, Linda
    • Other Affiliation: College of Medicine; University of Malawi
  • Mwapasa, Victor
    • Other Affiliation: College of Medicine; University of Malawi
  • van Eijk, Anna M.
    • Other Affiliation: Department of Clinical Sciences; Liverpool School of Tropical Medicine
  • Khairallah, Carole
    • Other Affiliation: Department of Clinical Sciences; Liverpool School of Tropical Medicine
  • Ali, Doreen
    • Other Affiliation: National Malaria Control Programme; Ministry of Health
  • Pace, Cheryl
    • Other Affiliation: Department of Clinical Sciences; Liverpool School of Tropical Medicine
  • Smedley, James
    • Other Affiliation: Department of Clinical Sciences; Liverpool School of Tropical Medicine
  • Thwai, Kyaw-Lay
    • Affiliation: Gillings School of Global Public Health, Department of Epidemiology
  • Levitt, Brandt
    • Other Affiliation: Department of Molecular Genetics and Microbiology; Duke University Medical Center
  • Wang, Duolao
    • ORCID: 0000-0003-2788-2464
    • Other Affiliation: Department of Clinical Sciences; Liverpool School of Tropical Medicine
  • Kang’ombe, Arthur
    • Other Affiliation: Department of Clinical Sciences; Liverpool School of Tropical Medicine
  • Faragher, Brian
    • Other Affiliation: Department of Clinical Sciences; Liverpool School of Tropical Medicine
  • Taylor, Steve M.
    • Affiliation: Gillings School of Global Public Health, Department of Epidemiology
    • Other Affiliation: Division of Infectious Diseases; Department of Medicine; Duke University School of Medicine
  • Meshnick, Steve
    • Affiliation: Gillings School of Global Public Health, Department of Epidemiology
  • ter Kuile, Feiko O.
    • Other Affiliation: Department of Clinical Sciences; Liverpool School of Tropical Medicine
Abstract
  • In Africa, most plasmodium infections during pregnancy remain asymptomatic, yet are associated with maternal anemia and low birthweight. WHO recommends intermittent preventive therapy in pregnancy with sulfadoxine-pyrimethamine (IPTp-SP). However, sulfadoxine-pyrimethamine (SP) efficacy is threatened by high-level parasite resistance. We conducted a trial to evaluate the efficacy and safety of scheduled intermittent screening with malaria rapid diagnostic tests (RDTs) and treatment of RDT-positive women with dihydroartemisinin-piperaquine (DP) as an alternative strategy to IPTp-SP.
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  • Article
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  • In Copyright
Journal title
  • PLoS Medicine
Journal volume
  • 13
Journal issue
  • 9
Page start
  • e1002124
Language
  • English
ISSN
  • 1549-1676
  • 1549-1277

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