Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent Public Deposited

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  • Guo, Yan
    • Other Affiliation: Department of Cancer Biology; Vanderbilt University
  • Warren Andersen, Shaneda
    • Other Affiliation: Division of Epidemiology; Department of Medicine; Vanderbilt-Ingram Cancer Center; Vanderbilt University School of Medicine
  • Shu, Xiao-Ou
    • Other Affiliation: Division of Epidemiology; Department of Medicine; Vanderbilt-Ingram Cancer Center; Vanderbilt University School of Medicine
  • Michailidou, Kyriaki
    • Other Affiliation: Centre for Cancer Genetic Epidemiology; Department of Public Health and Primary Care; University of Cambridge
  • Bolla, Manjeet K.
    • Other Affiliation: Centre for Cancer Genetic Epidemiology; Department of Public Health and Primary Care; University of Cambridge
  • Wang, Qin
    • Other Affiliation: Centre for Cancer Genetic Epidemiology; Department of Public Health and Primary Care; University of Cambridge
  • Garcia-Closas, Montserrat
    • Other Affiliation: Division of Genetics and Epidemiology; The Institute of Cancer Research
  • Milne, Roger L.
    • Other Affiliation: Cancer Epidemiology Centre; Cancer Council Victoria
  • Schmidt, Marjanka K.
    • Other Affiliation: Netherlands Cancer Institute; Antoni van Leeuwenhoek hospital
  • Chang-Claude, Jenny
    • Other Affiliation: Department of Obstetrics and Gynecology; University of Ulm
  • Dunning, Allison
    • Other Affiliation: Academic Unit of Pathology; Department of Neuroscience; University of Sheffield
  • Bojesen, Stig E.
    • Other Affiliation: Department of Clinical Biochemistry; Herlev Hospital; Copenhagen University Hospital
  • Ahsan, Habibul
    • Other Affiliation: Department of Health Studies; The University of Chicago
  • Aittomäki, Kristiina
    • Other Affiliation: Department of Clinical Genetics; Helsinki University Hospital; University of Helsinki
  • Andrulis, Irene L.
    • Other Affiliation: Department of Molecular Genetics; University of Toronto
  • Anton-Culver, Hoda
    • Other Affiliation: Department of Epidemiology; University of California Irvine
  • Arndt, Volker
    • ORCID: 0000-0001-9320-8684
    • Other Affiliation: Division of Clinical Epidemiology and Aging Research; German Cancer Research Center (DKFZ)
  • Beckmann, Matthias W.
    • Other Affiliation: Department of Health Studies; The University of Chicago
  • Beeghly-Fadiel, Alicia
    • Other Affiliation: Division of Epidemiology; Department of Medicine; Vanderbilt-Ingram Cancer Center; Vanderbilt University School of Medicine
  • Benitez, Javier
    • Other Affiliation: Centro de Investigación en Red de Enfermedades Raras
  • Bogdanova, Natalia V.
    • Other Affiliation: Department of Radiation Oncology; Hannover Medical School
  • Bonanni, Bernardo
    • Other Affiliation: Division of Cancer Prevention and Genetics; Istituto Europeo di Oncologia
  • Børresen-Dale, Anne-Lise
    • Other Affiliation: Department of Genetics; Institute for Cancer Research; Radiumhospitalet; Oslo University Hospital; Oslo University Hospital
  • Brand, Judith
    • Other Affiliation: Department of Medical Epidemiology and Biostatistics; Karolinska Institutet
  • Brauch, Hiltrud
    • Other Affiliation: University of Tübingen
  • Brenner, Hermann
    • Other Affiliation: Division of Clinical Epidemiology and Aging Research; German Cancer Research Center (DKFZ)
  • Brüning, Thomas
    • Other Affiliation: Institute for Prevention and Occupational Medicine of the German Social Accident Insurance; Institute of the Ruhr University Bochum
  • Burwinkel, Barbara
    • Other Affiliation: Division of Molecular Genetic Epidemiology; German Cancer Research Center (DKFZ)
  • Casey, Graham
    • Other Affiliation: Department of Preventive Medicine; Keck School of Medicine; University of Southern California
  • Chenevix-Trench, Georgia
    • Other Affiliation: Department of Genetics; QIMR Berghofer Medical Research Institute
  • Couch, Fergus J.
    • Other Affiliation: Department of Laboratory Medicine and Pathology; Mayo Clinic
  • Cox, Angela
    • ORCID: 0000-0002-5138-1099
    • Other Affiliation: Sheffield Cancer Research; Department of Oncology; University of Sheffield
  • Cross, Simon S.
    • Other Affiliation: Academic Unit of Pathology; Department of Neuroscience; University of Sheffield
  • Czene, Kamila
    • Other Affiliation: Department of Medical Epidemiology and Biostatistics; Karolinska Institutet
  • Devilee, Peter
    • ORCID: 0000-0002-8023-2009
    • Other Affiliation: Department of Human Genetics; Leiden University Medical Center
  • Dörk, Thilo
    • Other Affiliation: Gynaecology Research Unit; Hannover Medical School
  • Dumont, Martine
    • Other Affiliation: Centre Hospitalier Universitaire de Québec Research Center; Laval University
  • Fasching, Peter A.
    • Other Affiliation: Department of Gynaecology and Obstetrics; University Hospital Erlangen; Friedrich-Alexander University Erlangen-Nuremberg; Comprehensive Cancer Center Erlangen-EMN
  • Figueroa, Jonine
    • Other Affiliation: Division of Cancer Epidemiology and Genetics; National Cancer Institute
  • Flesch-Janys, Dieter
    • Other Affiliation: Department of Cancer Epidemiology; Clinical Cancer Registry; University Medical Center Hamburg-Eppendorf
  • Fletcher, Olivia
    • Other Affiliation: Breakthrough Breast Cancer Research Centre; The Institute of Cancer Research
  • Flyger, Henrik
    • Other Affiliation: Department of Breast Surgery; Herlev Hospital; Copenhagen University Hospital
  • Fostira, Florentia
    • Other Affiliation: Molecular Diagnostics Laboratory; IRRP; National Centre for Scientific Research "Demokritos"
  • Gammon, Marilie
    • Affiliation: Gillings School of Global Public Health, Department of Epidemiology
  • Giles, Graham G.
    • Other Affiliation: Cancer Epidemiology Centre; Cancer Council Victoria
  • Guénel, Pascal
    • Other Affiliation: Environmental Epidemiology of Cancer; Center for Research in Epidemiology and Population Health; INSERM
  • Haiman, Christopher A.
    • Other Affiliation: Department of Preventive Medicine; Keck School of Medicine; University of Southern California
  • Hamann, Ute
    • Other Affiliation: Molecular Genetics of Breast Cancer; German Cancer Research Center (DKFZ)
  • Hooning, Maartje J.
    • Other Affiliation: Department of Surgical Oncology; Erasmus University Medical Center
  • Hopper, John L.
    • Other Affiliation: Centre for Epidemiology and Biostatistics; School of Population and Global health; The University of Melbourne
  • Jakubowska, Anna
    • Other Affiliation: Department of Genetics and Pathology; Pomeranian Medical University
  • Jasmine, Farzana
    • Other Affiliation: Department of Health Studies; The University of Chicago
  • Jenkins, Mark
    • Other Affiliation: Centre for Epidemiology and Biostatistics; School of Population and Global health; The University of Melbourne
  • John, Esther M.
    • Other Affiliation: Department of Epidemiology; Cancer Prevention Institute of California
  • Johnson, Nichola
    • Other Affiliation: Breakthrough Breast Cancer Research Centre; The Institute of Cancer Research
  • Jones, Michael E.
    • Other Affiliation: Division of Genetics and Epidemiology; The Institute of Cancer Research
  • Kabisch, Maria
    • Other Affiliation: Molecular Genetics of Breast Cancer; German Cancer Research Center (DKFZ)
  • Kibriya, Muhammad
    • ORCID: 0000-0001-9784-6958
    • Other Affiliation: Department of Health Studies; The University of Chicago
  • Knight, Julia A.
    • Other Affiliation: Division of Epidemiology; Dalla Lana School of Public Health; University of Toronto
  • Koppert, Linetta B.
    • Other Affiliation: Department of Surgical Oncology; Erasmus University Medical Center
  • Kosma, Veli-Matti
    • Other Affiliation: Imaging Center; Department of Clinical Pathology; Kuopio University Hospital
  • Kristensen, Vessela
    • Other Affiliation: Department of Clinical Molecular Biology; Oslo University Hospital; University of Oslo
  • Le Marchand, Loic
    • Other Affiliation: University of Hawaii Cancer Center; Honolulu; Hawaii
  • Lee, Eunjung
    • Other Affiliation: Department of Preventive Medicine; Keck School of Medicine; University of Southern California
  • Li, Jingmei
    • Other Affiliation: Department of Medical Epidemiology and Biostatistics; Karolinska Institutet
  • Lindblom, Annika
    • Other Affiliation: Department of Molecular Medicine and Surgery; Karolinska Institutet
  • Luben, Robert
    • ORCID: 0000-0002-5088-6343
    • Other Affiliation: Clinical Gerontology; Department of Public Health and Primary Care; University of Cambridge
  • Lubinski, Jan
    • Other Affiliation: Department of Genetics and Pathology; Pomeranian Medical University
  • Malone, Kathi E.
    • Other Affiliation: Division of Public Health Sciences; Fred Hutchinson Cancer Research Center
  • Mannermaa, Arto
    • Other Affiliation: Imaging Center; Department of Clinical Pathology; Kuopio University Hospital
  • Margolin, Sara
    • Other Affiliation: Department of Oncology – Pathology; Karolinska Institutet
  • Marme, Frederik
    • Other Affiliation: National Center for Tumor Diseases; University of Heidelberg
  • McLean, Catriona
    • Other Affiliation: Anatomical Pathology; The Alfred Hospital
  • Meijers-Heijboer, Hanne
    • ORCID: 0000-0003-1169-3853
    • Other Affiliation: Department of Clinical Genetics; VU University Medical Center
  • Meindl, Alfons
    • Other Affiliation: Division of Gynaecology and Obstetrics; Technische Universität München
  • Neuhausen, Susan L.
    • Other Affiliation: Beckman Research Institute of City of Hope
  • Nevanlinna, Heli
    • Other Affiliation: Department of Obstetrics and Gynecology; Helsinki University Hospital; University of Helsinki
  • Neven, Patrick
    • Other Affiliation: Department of Oncology; University Hospital Gasthuisberg
  • Olson, Janet E.
    • Other Affiliation: Department of Health Sciences Research; Mayo Clinic
  • Perez, Jose I. A.
    • Other Affiliation: Servicio de Cirugía General y Especialidades; Hospital Monte Naranco
  • Perkins, Barbara
    • Other Affiliation: Centre for Cancer Genetic Epidemiology; Department of Oncology; University of Cambridge
  • Peterlongo, Paolo
    • ORCID: 0000-0001-6951-6855
    • Other Affiliation: IFOM; Fondazione Istituto FIRC (Italian Foundation of Cancer Research) di Oncologia Molecolare
  • Phillips, Kelly-Anne
    • Other Affiliation: Peter MacCallum Cancer Center; The University of Melbourne
  • Pylkäs, Katri
    • Other Affiliation: Laboratory of Cancer Genetics and Tumor Biology; Department of Clinical Chemistry and Biocenter Oulu; University of Oulu
  • Rudolph, Anja
    • Other Affiliation: Division of Cancer Epidemiology; German Cancer Research Center (DKFZ)
  • Santella, Regina
    • Other Affiliation: Herbert Irving Comprehensive Cancer Center; Columbia University Medical Center
  • Sawyer, Elinor J.
    • Other Affiliation: Research Oncology; Guy’s Hospital; King's College London; London
  • Schmutzler, Rita K.
    • Other Affiliation: Center for Integrated Oncology; University Hospital of Cologne
  • Seynaeve, Caroline
    • Other Affiliation: Department of Surgical Oncology; Erasmus University Medical Center
  • Shah, Mitul
    • Other Affiliation: Centre for Cancer Genetic Epidemiology; Department of Oncology; University of Cambridge
  • Shrubsole, Martha J.
    • Other Affiliation: Division of Epidemiology; Department of Medicine; Vanderbilt-Ingram Cancer Center; Vanderbilt University School of Medicine
  • Southey, Melissa C.
    • Other Affiliation: Department of Pathology; The University of Melbourne
  • Swerdlow, Anthony J.
    • Other Affiliation: Division of Genetics and Epidemiology; The Institute of Cancer Research
  • Toland, Amanda E.
    • Other Affiliation: Department of Molecular Virology; Immunology and Medical Genetics; Comprehensive Cancer Center; The Ohio State University
  • Tomlinson, Ian
    • Other Affiliation: Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre; University of Oxford
  • Torres, Diana
    • Other Affiliation: Molecular Genetics of Breast Cancer; German Cancer Research Center (DKFZ)
  • Truong, Thérèse
    • Other Affiliation: Environmental Epidemiology of Cancer; Center for Research in Epidemiology and Population Health; INSERM
  • Ursin, Giske
    • Other Affiliation: Department of Nutrition; Institute of Basic Medical Sciences; University of Oslo
  • Van Der Luijt, Rob B.
    • Other Affiliation: Department of Medical Genetics; University Medical Center Utrecht
  • Verhoef, Senno
    • Other Affiliation: Netherlands Cancer Institute; Antoni van Leeuwenhoek hospital
  • Whittemore, Alice S.
    • Other Affiliation: Department of Health Research and Policy; Stanford University School of Medicine
  • Winqvist, Robert
    • Other Affiliation: Laboratory of Cancer Genetics and Tumor Biology; Department of Clinical Chemistry and Biocenter Oulu; University of Oulu
  • Zhao, Hui
    • Other Affiliation: Vesalius Research Center
  • Zhao, Shilin
    • Other Affiliation: Department of Cancer Biology; Vanderbilt University
  • Hall, Per
    • Other Affiliation: Department of Medical Epidemiology and Biostatistics; Karolinska Institutet
  • Simard, Jacques
    • Other Affiliation: Centre Hospitalier Universitaire de Québec Research Center; Laval University
  • Kraft, Peter
    • Other Affiliation: Program in Genetic Epidemiology and Statistical Genetics; Harvard School of Public Health
  • Pharoah, Paul
    • ORCID: 0000-0001-8494-732X
    • Other Affiliation: Centre for Cancer Genetic Epidemiology; Department of Oncology; University of Cambridge
  • Hunter, David
    • Other Affiliation: Program in Genetic Epidemiology and Statistical Genetics; Harvard School of Public Health
  • Easton, Douglas F.
    • Other Affiliation: Centre for Cancer Genetic Epidemiology; Department of Oncology; University of Cambridge
  • Zheng, Wei
    • Other Affiliation: Division of Epidemiology; Department of Medicine; Vanderbilt-Ingram Cancer Center; Vanderbilt University School of Medicine
Abstract
  • Observational epidemiological studies have shown that high body mass index (BMI) is associated with a reduced risk of breast cancer in premenopausal women but an increased risk in postmenopausal women. It is unclear whether this association is mediated through shared genetic or environmental factors.
Date of publication
Keyword
DOI
Identifier
Resource type
  • Article
Rights statement
  • In Copyright
Journal title
  • PLoS Medicine
Journal volume
  • 13
Journal issue
  • 8
Page start
  • e1002105
Language
  • English
ISSN
  • 1549-1277
  • 1549-1676
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