Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders

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  • Weiner, Daniel J.
    • Other Affiliation: Analytic and Translational Genetics Unit; Department of Medicine; Massachusetts General Hospital; Harvard Medical School
  • Wigdor, Emilie M.
    • Other Affiliation: Analytic and Translational Genetics Unit; Department of Medicine; Massachusetts General Hospital; Harvard Medical School
  • Ripke, Stephan
    • Other Affiliation: Analytic and Translational Genetics Unit; Department of Medicine; Massachusetts General Hospital; Harvard Medical School
  • Walters, Raymond K.
    • Other Affiliation: Analytic and Translational Genetics Unit; Department of Medicine; Massachusetts General Hospital; Harvard Medical School
  • Kosmicki, Jack A.
    • Other Affiliation: Analytic and Translational Genetics Unit; Department of Medicine; Massachusetts General Hospital; Harvard Medical School
  • Grove, Jakob
    • Other Affiliation: Lundbeck Foundation Initiative for Integrative Psychiatric Research; IPSYCH
  • Samocha, Kaitlin E.
    • Other Affiliation: Analytic and Translational Genetics Unit; Department of Medicine; Massachusetts General Hospital; Harvard Medical School
  • Goldstein, Jacqueline I.
    • Other Affiliation: Analytic and Translational Genetics Unit; Department of Medicine; Massachusetts General Hospital; Harvard Medical School
  • Okbay, Aysu
    • Other Affiliation: Department of Complex Trait Genetics; Center for Neurogenomics and Cognitive Research; Vrije Universiteit Amsterdam
  • Bybjerg-Grauholm, Jonas
    • Other Affiliation: Lundbeck Foundation Initiative for Integrative Psychiatric Research; IPSYCH
  • Werge, Thomas
    • Other Affiliation: Lundbeck Foundation Initiative for Integrative Psychiatric Research; IPSYCH
  • Hougaard, David M
    • Other Affiliation: Danish Center for Neonatal Screening; Department for Congenital Disorders; Statens Serum Institut
  • Taylor, Jacob
    • Other Affiliation: Analytic and Translational Genetics Unit; Department of Medicine; Massachusetts General Hospital; Harvard Medical School
  • Skuse, David
    • Other Affiliation: Behavioural Sciences Unit; Institute of Child Health; University College London
  • Devlin, Bernie
    • Other Affiliation: Department of Psychiatry; University of Pittsburgh School of Medicine
  • Anney, Richard
    • Other Affiliation: Division of Psychological Medicine and Clinical Neurosciences; Cardiff University
  • Sanders, Stephan J
    • Other Affiliation: Department of Psychiatry; UCSF Weill Institute for Neurosciences; University of California; San Francisco
  • Bishop, Somer
    • Other Affiliation: Department of Psychiatry; UCSF Weill Institute for Neurosciences; University of California; San Francisco
  • Mortensen, Preben Bo
    • Other Affiliation: Lundbeck Foundation Initiative for Integrative Psychiatric Research; IPSYCH
  • Børglum, Anders D
    • Other Affiliation: Lundbeck Foundation Initiative for Integrative Psychiatric Research; IPSYCH
  • Smith, George Davey
    • Other Affiliation: Medical Research Council Integrative Epidemiology Unit; University of Bristol
  • Daly, Mark J
    • Other Affiliation: Analytic and Translational Genetics Unit; Department of Medicine; Massachusetts General Hospital; Harvard Medical School
  • Robinson, Elise B.
    • Other Affiliation: Analytic and Translational Genetics Unit; Department of Medicine; Massachusetts General Hospital; Harvard Medical School
  • Bækvad-Hansen, Marie
    • Other Affiliation: Lundbeck Foundation Initiative for Integrative Psychiatric Research; IPSYCH
  • Dumont, Ashley
    • Other Affiliation: Stanley Center for Psychiatric Research; Broad Institute of mit and Harvard
  • Hansen, Christine
    • Other Affiliation: Lundbeck Foundation Initiative for Integrative Psychiatric Research; IPSYCH
  • Hansen, Thomas F.
    • Other Affiliation: Lundbeck Foundation Initiative for Integrative Psychiatric Research; IPSYCH
  • Howrigan, Daniel
    • Other Affiliation: Analytic and Translational Genetics Unit; Department of Medicine; Massachusetts General Hospital; Harvard Medical School
  • Mattheisen, Manuel
    • Other Affiliation: Lundbeck Foundation Initiative for Integrative Psychiatric Research; IPSYCH
  • Moran, Jennifer
    • Other Affiliation: Stanley Center for Psychiatric Research; Broad Institute of mit and Harvard
  • Mors, Ole
    • Other Affiliation: Lundbeck Foundation Initiative for Integrative Psychiatric Research; IPSYCH
  • Nordentoft, Merete
    • Other Affiliation: Lundbeck Foundation Initiative for Integrative Psychiatric Research; IPSYCH
  • Nørgaard-Pedersen, Bent
    • Other Affiliation: Lundbeck Foundation Initiative for Integrative Psychiatric Research; IPSYCH
  • Poterba, Timothy
    • Other Affiliation: Analytic and Translational Genetics Unit; Department of Medicine; Massachusetts General Hospital; Harvard Medical School
  • Poulsen, Jesper
    • Other Affiliation: Lundbeck Foundation Initiative for Integrative Psychiatric Research; IPSYCH
  • Stevens, Christine
    • Other Affiliation: Stanley Center for Psychiatric Research; Broad Institute of mit and Harvard
  • Anttila, Verneri
    • Other Affiliation: Analytic and Translational Genetics Unit; Department of Medicine; Massachusetts General Hospital; Harvard Medical School
  • Holmans, Peter
    • Other Affiliation: MRC Centre for Neuropsychiatric Genetics and Genomics; Cardiff University
  • Huang, Hailiang
    • Other Affiliation: Analytic and Translational Genetics Unit; Department of Medicine; Massachusetts General Hospital; Harvard Medical School
  • Klei, Lambertus
    • Other Affiliation: Division of Psychological Medicine and Clinical Neurosciences; Cardiff University
  • Lee, Phil H.
    • Other Affiliation: Analytic and Translational Genetics Unit; Department of Medicine; Massachusetts General Hospital; Harvard Medical School
  • Medland, Sarah E.
    • Other Affiliation: Queensland Institute of Medical Research
  • Neale, Benjamin
    • Other Affiliation: Analytic and Translational Genetics Unit; Department of Medicine; Massachusetts General Hospital; Harvard Medical School
  • Weiss, Lauren A.
    • Other Affiliation: Institute of Human Genetics; University of California; San Francisco
  • Zwaigenbaum, Lonnie
    • Other Affiliation: Department of Pediatrics; University of Alberta
  • Yu, Timothy W.
    • Other Affiliation: Division of Genetics; Children's Hospital Boston; Harvard Medical School
  • Wittemeyer, Kerstin
    • Other Affiliation: School of Education; University of Birmingham
  • Willsey, A Jeremy
    • Other Affiliation: Department of Psychiatry; University of California; San Francisco
  • Wijsman, Ellen M.
    • Other Affiliation: Department of Biostatistics; University of Washington
  • Wassink, Thomas H.
    • Other Affiliation: Department of Psychiatry; Carver College of Medicine
  • Waltes, Regina
    • Other Affiliation: Department of Child and Adolescent Psychiatry; Psychosomatics and Psychotherapy; JW Goethe University Frankfurt
  • Walsh, Christopher A.
    • Other Affiliation: Department of Pediatrics; Harvard Medical School
  • Wallace, Simon
    • Other Affiliation: Department of Psychiatry; University of Oxford; Warneford Hospital
  • Vorstman, Jacob A. S.
    • Other Affiliation: Department of Psychiatry; Brain Center Rudolf Magnus; University Medical Center Utrecht
  • Vieland, Veronica J.
    • Other Affiliation: Battelle Center for Mathematical Medicine; Research Institute at Nationwide Children's Hospital
  • Vicente, Astrid M.
    • Other Affiliation: Instituto Nacional de Saoede Dr. Ricardo Jorge
  • Van Engeland, Herman
    • Other Affiliation: Department of Psychiatry; Brain Center Rudolf Magnus; University Medical Center Utrecht
  • Tsang, Kathryn
    • Other Affiliation: Institute of Human Genetics; University of California; San Francisco
  • Thompson, Ann P.
    • Other Affiliation: Department of Psychiatry and Behavioral Neurosciences; McMaster University
  • Szatmari, Peter
    • Other Affiliation: Department of Psychiatry; University of Toronto
  • Svantesson, Oscar
    • Other Affiliation: Karolinska Institutet
  • Steinberg, Stacy
    • Other Affiliation: DeCODE Genetics
  • Stefansson, Kari
    • Other Affiliation: DeCODE Genetics
  • Stefansson, Hreinn
    • Other Affiliation: DeCODE Genetics
  • State, Matthew W.
    • Other Affiliation: Department of Psychiatry; University of California; San Francisco
  • Soorya, Latha
    • Other Affiliation: Department of Psychiatry; Icahn School of Medicine at Mount Sinai
  • Silagadze, Teimuraz
    • Other Affiliation: Department of Psychiatry and Drug Addiction; Tbilisi State Medical University
  • Scherer, Stephen W.
    • Other Affiliation: McLaughlin Centre; University of Toronto
  • Schellenberg, Gerard D.
    • Other Affiliation: Department of Pathology and Laboratory Medicine; University of Pennsylvania
  • Sandin, Sven
    • Other Affiliation: State Diagnostic and Counseling Centre
  • Saemundsen, Evald
    • Other Affiliation: State Diagnostic and Counseling Centre
  • Rouleau, Guy A.
    • Other Affiliation: Montreal Neurological Institute; Department of Neurology and Neurosurgery; McGill University
  • Rogé, Bernadette
    • Other Affiliation: Centre d'Etudes et de Recherches en Psychopathologie; Toulouse University
  • Roeder, Kathryn
    • Other Affiliation: Department of Computational Biology; Carnegie Mellon University
  • Roberts, Wendy
    • Other Affiliation: Autism Research Unit; Hospital for Sick Children
  • Reichert, Jennifer
    • Other Affiliation: Department of Psychiatry; Icahn School of Medicine at Mount Sinai
  • Reichenberg, Abraham
    • Other Affiliation: Department of Psychiatry; Icahn School of Medicine at Mount Sinai
  • Rehnström, Karola
    • Other Affiliation: Sanger Institute
  • Regan, Regina
    • Other Affiliation: Academic Centre on Rare Diseases; University College Dublin
  • Poustka, Fritz
    • Other Affiliation: Department of Child and Adolescent Psychiatry; Psychosomatics and Psychotherapy; JW Goethe University Frankfurt
  • Poultney, Christopher S.
    • Other Affiliation: Department of Psychiatry; Icahn School of Medicine at Mount Sinai
  • Piven, Joseph
    • Affiliation: School of Medicine, Department of Psychiatry
  • Pinto, Dalila
    • Other Affiliation: Department of Psychiatry; Icahn School of Medicine at Mount Sinai
  • Pericak-Vance, Margaret A.
    • Other Affiliation: John P. Hussman Institute for Human Genomics; University of Miami
  • Pejovic-Milovancevic, Milica
    • Other Affiliation: Institute of Mental Health and Medical Faculty; University of Belgrade
  • Pedersen, Marianne G.
    • Other Affiliation: Centre for Integrated Register-based Research; Aarhus University
  • Pedersen, Carsten B.
    • Other Affiliation: Centre for Integrated Register-based Research; Aarhus University
  • Paterson, Andrew D.
    • Other Affiliation: Department of Molecular Genetics; University of Toronto
  • Parr, Jeremy R.
    • Other Affiliation: Institue of Health and Science; Newcastle University
  • Pagnamenta, Alistair T.
    • Other Affiliation: Wellcome Trust Centre for Human Genetics; Oxford University
  • Oliveira, Guiomar
    • Other Affiliation: Unidade de Neurodesenvolvimento e Autismo Do Servico Do Centro de Desenvolvimento da Crianca; Centro de Investigação e Formação Clinica; Pediatric Hospital; Centro Hospitalar e Universitário de Coimbra
  • Nurnberger, John I.
    • Other Affiliation: Department of Medical and Molecular Genetics; Indiana University School of Medicine
  • Murtha, Michael T.
    • Other Affiliation: Programs on Neurogenetics; Yale University School of Medicine
  • Mouga, Susana
    • Other Affiliation: Unidade de Neurodesenvolvimento e Autismo Do Servico Do Centro de Desenvolvimento da Crianca; Centro de Investigação e Formação Clinica; Pediatric Hospital; Centro Hospitalar e Universitário de Coimbra
  • Morrow, Eric M.
    • Other Affiliation: Department of Psychiatry and Human Behavior; Brown University
  • DeLuca, Daniel Moreno
    • Other Affiliation: Department of Psychiatry and Human Behavior; Brown University
  • Monaco, Anthony P.
    • Other Affiliation: Wellcome Trust Centre for Human Genetics; Oxford University
  • Minshew, Nancy
    • Other Affiliation: Division of Psychological Medicine and Clinical Neurosciences; Cardiff University
  • Merikangas, Alison
    • Other Affiliation: Department of Psychiatry; Trinity College Dublin
  • McMahon, William M.
    • Other Affiliation: Department of Psychiatry; University of Utah
  • McGrew, Susan G.
    • Other Affiliation: Department of Pediatrics; Vanderbilt University
  • Martsenkovsky, Igor
    • Other Affiliation: Department of Child; Adolescent Psychiatry and Medical-Social Rehabilitation; Ukrainian Research Institute of Social Forensic Psychiatry and Drug Abuse
  • Martin, Donna M.
    • Other Affiliation: Department of Pediatrics and Human Genetics; University of Michigan
  • Mane, Shrikant M.
    • Other Affiliation: Yale Center for Genomic Analysis; Yale University School of Medicine
  • Magnusson, Pall
    • Other Affiliation: Department of Child and Adolescent Psychiatry; National University Hospital
  • Magalhaes, Tiago
    • Other Affiliation: Academic Centre on Rare Diseases; University College Dublin
  • Maestrini, Elena
    • Other Affiliation: Department of Pharmacy and Biotechnology; University of Bologna
  • Lowe, Jennifer K.
    • Other Affiliation: Program in Neurogenetics; Department of Neurology; David Geffen School of Medicine; University of California; Los Angeles
  • Lord, Catherine
    • Other Affiliation: Department of Psychiatry; Weill Cornell Medical College; Cornell University
  • Levitt, Pat
    • Other Affiliation: Department of Pediatrics; Keck School of Medicine; University of Southern California
  • Martin, Christa Lese
    • Other Affiliation: Autism and Developmental Medicine Institute; Geisinger Health System
  • Ledbetter, David H.
    • Other Affiliation: Geisinger Health System
  • Leboyer, Marion
    • Other Affiliation: FondaMental Foundation
  • LeCouteur, Ann S.
    • Other Affiliation: Institue of Health and Science; Newcastle University
  • Ladd-Acosta, Christine
    • Other Affiliation: Department of Epidemiology; Johns Hopkins Bloomberg School of Public Health
  • Kolevzon, Alexander
    • Other Affiliation: Department of Psychiatry; Icahn School of Medicine at Mount Sinai
  • Klauck, Sabine M.
    • Other Affiliation: Division of Molecular Genome Analysis and Working Group Cancer Genome Research; Deutsches Krebsforschungszentrum
  • Jacob, Suma
    • Other Affiliation: Institute for Juvenile Research; Department of Psychiatry; University of Illinois at Chicago
  • Iliadou, Bozenna
    • Other Affiliation: Karolinska Institutet
  • Hultman, Christina M.
    • Other Affiliation: Karolinska Institutet
  • Hertz-Picciotto, Irva
    • Other Affiliation: MIND Institute; School of Medicine; University of California; Davis
  • Hendren, Robert
    • Other Affiliation: Department of Psychiatry; University of California; San Francisco
  • Hansen, Christine S.
    • Other Affiliation: Lundbeck Foundation Initiative for Integrative Psychiatric Research; IPSYCH
  • Haines, Jonathan L.
    • Other Affiliation: Department of Molecular Physiology and Biophysics; Vanderbilt University
  • Guter, Stephen J.
    • Other Affiliation: Institute for Juvenile Research; Department of Psychiatry; University of Illinois at Chicago
  • Grice, Dorothy E.
    • Other Affiliation: Department of Psychiatry; Icahn School of Medicine at Mount Sinai
  • Green, Jonathan M.
    • Other Affiliation: Institute of Brain; Behaviour and Mental Health; University of Manchester
  • Green, Andrew
    • Other Affiliation: Academic Centre on Rare Diseases; University College Dublin
  • Goldberg, Arthur P.
    • Other Affiliation: Department of Genetics and Genomic Sciences; Icahn School of Medicine at Mount Sinai
  • Gillberg, Christopher
    • Other Affiliation: Gillberg Neuropsychiatry Centre; University of Gothenburg
  • Gilbert, John
    • Other Affiliation: John P. Hussman Institute for Human Genomics; University of Miami
  • Gallagher, Louise
    • Other Affiliation: Department of Psychiatry; Trinity College Dublin
  • Freitag, Christine M.
    • Other Affiliation: Department of Child and Adolescent Psychiatry; Psychosomatics and Psychotherapy; JW Goethe University Frankfurt
  • Fombonne, Eric
    • Other Affiliation: Department of Psychiatry; Institute for Development and Disability; Oregon Health and Science University
  • Folstein, Susan E.
    • Other Affiliation: Division of Child and Adolescent Psychiatry; Department of Psychiatry; Miller School of Medicine; University of Miami
  • Fernandez, Bridget
    • Other Affiliation: Disciplines of Genetics and Medicine; Memorial University of Newfoundland
  • Fallin, M. Daniele
    • Other Affiliation: Department of Mental Health; Johns Hopkins Bloomberg School of Public Health
  • Ercan-Sencicek, A. Gulhan
    • Other Affiliation: Programs on Neurogenetics; Yale University School of Medicine
  • Ennis, Sean
    • Other Affiliation: Academic Centre on Rare Diseases; University College Dublin
  • Duque, Frederico
    • Other Affiliation: Unidade de Neurodesenvolvimento e Autismo Do Servico Do Centro de Desenvolvimento da Crianca; Centro de Investigação e Formação Clinica; Pediatric Hospital; Centro Hospitalar e Universitário de Coimbra
  • Duketis, Eftichia
    • Other Affiliation: Department of Child and Adolescent Psychiatry; Psychosomatics and Psychotherapy; JW Goethe University Frankfurt
  • Delorme, Richard
    • Other Affiliation: FondaMental Foundation
  • DeRubeis, Silvia
    • Other Affiliation: Department of Psychiatry; Icahn School of Medicine at Mount Sinai
  • DeJonge, Maretha V.
    • Other Affiliation: Department of Psychiatry; Brain Center Rudolf Magnus; University Medical Center Utrecht
  • Dawson, Geraldine
    • Other Affiliation: Duke Institute for Brain Sciences; Duke University School of Medicine
  • Cuccaro, Michael L.
    • Other Affiliation: John P. Hussman Institute for Human Genomics; University of Miami
  • Correia, Catarina T.
    • Other Affiliation: Instituto Nacional de Saoede Dr. Ricardo Jorge
  • Conroy, Judith
    • Other Affiliation: Academic Centre on Rare Diseases; University College Dublin
  • Conceição, Inês C.
    • Other Affiliation: Instituto Nacional de Saoede Dr. Ricardo Jorge
  • Chiocchetti, Andreas G.
    • Other Affiliation: Department of Child and Adolescent Psychiatry; Psychosomatics and Psychotherapy; JW Goethe University Frankfurt
  • Celestino-Soper, Patrícia B. S.
    • Other Affiliation: Department of Medical and Molecular Genetics; Indiana University School of Medicine
  • Casey, Jillian
    • Other Affiliation: Academic Centre on Rare Diseases; University College Dublin
  • Cantor, Rita M.
    • Other Affiliation: Department of Psychiatry; David Geffen School of Medicine; University of California; Los Angeles
  • Cafe, Cátia
    • Other Affiliation: Unidade de Neurodesenvolvimento e Autismo Do Servico Do Centro de Desenvolvimento da Crianca; Centro de Investigação e Formação Clinica; Pediatric Hospital; Centro Hospitalar e Universitário de Coimbra
  • Brennan, Sean
    • Other Affiliation: Department of Psychiatry; Trinity College Dublin
  • Bourgeron, Thomas
    • Other Affiliation: FondaMental Foundation
  • Bolton, Patrick F.
    • Other Affiliation: Institute of Psychiatry; Kings College London
  • Bölte, Sven
    • Other Affiliation: Department of Child and Adolescent Psychiatry; Psychosomatics and Psychotherapy; JW Goethe University Frankfurt
  • Bolshakova, Nadia
    • Other Affiliation: Department of Psychiatry; Trinity College Dublin
  • Betancur, Catalina
    • Other Affiliation: Sorbonne Universités; UPMC Université Paris 6; Neuroscience Paris Seine
  • Bernier, Raphael
    • Other Affiliation: Department of Psychiatry and Behavioral Sciences; University of Washington
  • Beaudet, Arthur L.
    • Other Affiliation: Department of Molecular and Human Genetics; Baylor College of Medicine
  • Battaglia, Agatino
    • Other Affiliation: Stella Maris Institute for Child and Adolescent Neuropsychiatr
  • Bal, Vanessa H.
    • Other Affiliation: Department of Psychiatry; University of California; San Francisco
  • Baird, Gillian
    • Other Affiliation: Paediatric Neurodisability; King's Health Partners; Kings College London
  • Bailey, Anthony J.
    • Other Affiliation: Mental Health and Addictions Research Unit; University of British Colombia
  • Bader, Joel S.
    • Other Affiliation: McKusick-Nathans Institute of Genetic Medicine; Johns Hopkins University
  • Bacchelli, Elena
    • Other Affiliation: Department of Pharmacy and Biotechnology; University of Bologna
  • Anagnostou, Evdokia
    • Other Affiliation: Bloorview Research Institute; University of Toronto
  • Amaral, David
    • Other Affiliation: MIND Institute; School of Medicine; University of California; Davis
  • Almeida, Joana
    • Other Affiliation: Unidade de Neurodesenvolvimento e Autismo Do Servico Do Centro de Desenvolvimento da Crianca; Centro de Investigação e Formação Clinica; Pediatric Hospital; Centro Hospitalar e Universitário de Coimbra
  • Buxbaum, Joseph D.
    • Other Affiliation: Department of Neuroscience; Icahn School of Medicine at Mount Sinai
  • Chakravarti, Aravinda
    • Other Affiliation: McKusick-Nathans Institute of Genetic Medicine; Johns Hopkins University
  • Cook, Edwin H.
    • Other Affiliation: Institute for Juvenile Research; Department of Psychiatry; University of Illinois at Chicago
  • Coon, Hilary
    • Other Affiliation: Department of Psychiatry; University of Utah
  • Geschwind, Daniel H.
    • Other Affiliation: Program in Neurogenetics; Department of Neurology; David Geffen School of Medicine; University of California; Los Angeles
  • Gill, Michael
    • Other Affiliation: Department of Psychiatry; Trinity College Dublin
  • Hakonarson, Hakon
    • Other Affiliation: Department of Pediatrics; University of Pennsylvania
  • Hallmayer, Joachim
    • Other Affiliation: Department of Psychiatry; Stanford University
  • Palotie, Aarno
    • Other Affiliation: Sanger Institute
  • Santangelo, Susan
    • Other Affiliation: Maine Medical Center Research Institute
  • Sutcliffe, James S.
    • Other Affiliation: Department of Molecular Physiology and Biophysics; Vanderbilt University
  • Arking, Dan E.
    • Other Affiliation: McKusick-Nathans Institute of Genetic Medicine; Johns Hopkins University
Abstract
  • Autism spectrum disorder (ASD) risk is influenced by common polygenic and de novo variation. We aimed to clarify the influence of polygenic risk for ASDs and to identify subgroups of ASD cases, including those with strong acting de novo variants, in which polygenic risk is relevant. Using a novel approach called the polygenic transmission disequilibrium test, and data from 6,454 families with a child with ASD, we show that polygenic risk for ASDs, schizophrenia, and greater educational attainment is over transmitted to children with ASDs. These findings hold independent of proband IQ. We find that polygenic variation contributes additively to risk in ASD cases who carry a strong acting de novo variant. Lastly, we show that elements of polygenic risk are independent and differ in their relationship with phenotype. These results confirm that ASDs’ genetic influences are additive and suggest they create risk through at least partially distinct etiologic pathways.
Date of publication
Keyword
DOI
Identifier
Resource type
  • Article
Rights statement
  • In Copyright
Journal title
  • Nature Genetics
Journal volume
  • 49
Journal issue
  • 7
Page start
  • 978
Page end
  • 985
Language
  • English
ISSN
  • 1546-1718
  • 1061-4036

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