Defining Salivary Biomarkers Using Mass Spectrometry-Based Proteomics: A Systematic Review

Creator

Al-Tarawneh, Sandra K.
- Affiliation: School of Dentistry
Border, Michael B.
- Affiliation: School of Dentistry
- Other Affiliation: University of Mount Union
Dibble, Christopher F.
- Affiliation: School of Medicine
Bencharit, Sompop
- Affiliation: School of Dentistry

Abstract

Recent advancements in mass spectrometric proteomics provide a promising result in utilizing saliva to explore biomarkers for diagnostic purposes. However, the issues of specificity or redundancy of disease-associated salivary biomarkers have not been described. This systematic review was therefore aimed to define and summarize disease-related salivary biomarkers identified by mass spectrometry proteomics. Peer-reviewed articles published through July 2009 within three databases were reviewed. Out of 243 articles, 21 studies were selected in this systematic review with conditions including Sjögren's syndrome, squamous cell carcinoma, dental caries, diabetes, breast cancer, periodontitis, gastric cancer, systemic sclerosis, oral lichen planus, bleeding oral cavity, and graft-versus-host disease. The sample size ranged from 3–41 in both diseased and control subjects, with no consensus on sample collection protocol. One hundred eighty biomarkers were identified in total; 87 upregulated, 63 downregulated, and 30 varying based on disease. Except for Sjögren's syndrome, the majority of studies with the same disease produce inconsistent biomarkers. Larger sample size and standardization of sample collection/treatment protocol may improve future studies.

Date of publication

Keyword

DOI

Identifier

Resource type

Rights statement

Journal title

Journal volume

Journal issue

Page start

Page end

Language

ISSN

Relations

Thumbnail	Title	Date Uploaded	Visibility	Actions
	EuropePMC-PMC3125555.pdf	2020-10-31	Public	Download