An original phylogenetic approach identified mitochondrial haplogroup T1a1 as inversely associated with breast cancer risk in BRCA2 mutation carriers
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Blein, Sophie, et al. An Original Phylogenetic Approach Identified Mitochondrial Haplogroup T1a1 As Inversely Associated with Breast Cancer Risk In Brca2 Mutation Carriers. BioMed Central, 2015. https://doi.org/10.17615/fxrh-w661APA
Blein, S., Bardel, C., Danjean, V., Mc Guffog, L., Healey, S., Barrowdale, D., Lee, A., Dennis, J., Kuchenbaecker, K., Soucy, P., Terry, M., Chung, W., Goldgar, D., Buys, S., Janavicius, R., Tihomirova, L., Tung, N., Dorfling, C., Van Rensburg, E., Neuhausen, S., Ding, Y., Gerdes, A., Ejlertsen, B., Nielsen, F., Hansen, T., Osorio, A., Benitez, J., Conejero, R., Segota, E., Weitzel, J., Thelander, M., Peterlongo, P., Radice, P., Pensotti, V., Dolcetti, R., Bonanni, B., Peissel, B., Zaffaroni, D., Scuvera, G., Manoukian, S., Varesco, L., Capone, G., Papi, L., Ottini, L., Yannoukakos, D., Konstantopoulou, I., Garber, J., Hamann, U., Donaldson, A., Brady, A., Brewer, C., Foo, C., Evans, D., Frost, D., Eccles, D., Douglas, F., Cook, J., Adlard, J., Barwell, J., Walker, L., Izatt, L., Side, L., Kennedy, M., Tischkowitz, M., Rogers, M., Porteous, M., Morrison, P., Platte, R., Eeles, R., Davidson, R., Hodgson, S., Cole, T., Godwin, A., Isaacs, C., Claes, K., De Leeneer, K., Meindl, A., Gehrig, A., Wappenschmidt, B., Sutter, C., Engel, C., Niederacher, D., Steinemann, D., Plendl, H., Kast, K., Rhiem, K., Ditsch, N., Arnold, N., Varon Mateeva, R., Schmutzler, R., Preisler Adams, S., Markov, N., Wang Gohrke, S., De Pauw, A., Lefol, C., Lasset, C., Leroux, D., Rouleau, E., Damiola, F., Dreyfus, H., Barjhoux, L., Golmard, L., Uhrhammer, N., Bonadona, V., Sornin, V., Bignon, Y., Carter, J., Van Le, L., Piedmonte, M., Di Silvestro, P., De La Hoya, M., Caldes, T., Nevanlinna, H., Aittomäki, K., Jager, A., Van Den Ouweland, A., Kets, C., Aalfs, C., Van Leeuwen, F., Hogervorst, F., Meijers Heijboer, H., Oosterwijk, J., Van Roozendaal, K., Rookus, M., Devilee, P., Van Der Luijt, R., Olah, E., Diez, O., Teulé, A., Lazaro, C., Blanco, I., Del Valle, J., Jakubowska, A., Sukiennicki, G., Gronwald, J., Lubinski, J., Durda, K., Jaworska Bieniek, K., Agnarsson, B., Maugard, C., Amadori, A., Montagna, M., Teixeira, M., Spurdle, A., Foulkes, W., Olswold, C., Lindor, N., Pankratz, V., Szabo, C., Lincoln, A., Jacobs, L., Corines, M., Robson, M., Vijai, J., Berger, A., Fink Retter, A., Singer, C., Rappaport, C., Kaulich, D., Pfeiler, G., Tea, M., Greene, M., Mai, P., Rennert, G., Imyanitov, E., Mulligan, A., Glendon, G., Andrulis, I., Tchatchou, S., Toland, A., Pedersen, I., Thomassen, M., Kruse, T., Jensen, U., Caligo, M., Friedman, E., Zidan, J., Laitman, Y., Lindblom, A., Melin, B., Arver, B., Loman, N., Rosenquist, R., Olopade, O., Nussbaum, R., Ramus, S., Nathanson, K., Domchek, S., Rebbeck, T., Arun, B., Mitchell, G., Karlan, B., Lester, J., Orsulic, S., Stoppa Lyonnet, D., Thomas, G., Simard, J., Couch, F., Offit, K., Easton, D., Chenevix Trench, G., Antoniou, A., Mazoyer, S., Phelan, C., Sinilnikova, O., & Cox, D. (2015). An original phylogenetic approach identified mitochondrial haplogroup T1a1 as inversely associated with breast cancer risk in BRCA2 mutation carriers. BioMed Central. https://doi.org/10.17615/fxrh-w661Chicago
Blein, Sophie, Claire Bardel, Vincent Danjean, Lesley Mc Guffog, Sue Healey, Daniel Barrowdale, Andrew Lee et al. 2015. An Original Phylogenetic Approach Identified Mitochondrial Haplogroup T1a1 As Inversely Associated with Breast Cancer Risk In Brca2 Mutation Carriers. BioMed Central. https://doi.org/10.17615/fxrh-w661- Creator
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Blein, Sophie
- Other Affiliation: INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France; Université de Lyon, Lyon, France; Université Lyon 1, Villeurbanne, France
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Bardel, Claire
- Other Affiliation: Université de Lyon, Lyon, France; Université Lyon 1, Villeurbanne, France; UMR CNRS 5558, Laboratoire de Biométrie et Biologie Évolutive (LBBE), “Biométrie et Biologie Évolutive”, Université Claude Bernard Lyon 1, Bâtiment Grégor Mendel, Villeurbanne, France
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Danjean, Vincent
- Other Affiliation: Université Grenoble Alpes, UMR 5217, Laboratoire d’Informatique de Grenoble (LIG), équipe-projet Multi-programmation et Ordonnancement sur ressources pour les Applications Interactives de Simulation (MOAIS), Grenoble, France; INRIA Rhône-Alpes, équipe-projet MOAIS, Saint Ismier, France
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McGuffog, Lesley
- Other Affiliation: Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
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Healey, Sue
- Other Affiliation: Department of Genetics and Computational Biology, QIMR Berghofer, Brisbane, Australia
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Barrowdale, Daniel
- Other Affiliation: Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
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Lee, Andrew
- Other Affiliation: Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
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Dennis, Joe
- Other Affiliation: Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
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Kuchenbaecker, Karoline B
- Other Affiliation: Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
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Soucy, Penny
- Other Affiliation: Centre de recherche du Centre hospitalier universitaire de Québec, Laval University, Charlesbourg, Canada
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Terry, Mary B
- Other Affiliation: Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, USA
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Chung, Wendy K
- Other Affiliation: Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, USA; Department of Medicine, Columbia University College of Physicians and Surgeons, New York, USA
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Goldgar, David E
- Other Affiliation: Department of Dermatology, University of Utah School of Medicine, Salt Lake City, USA
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Buys, Saundra S
- Other Affiliation: Department of Internal Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, USA
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Janavicius, Ramunas
- Other Affiliation: Hematology, Oncology and Transfusion Medicine Center, Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania; Department of Molecular and Regenerative Medicine, Centre for Innovative Medicine, State Research Institute, Vilnius, Lithuania
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Tihomirova, Laima
- Other Affiliation: Latvian Biomedical Research and Study Centre, Rīga, Latvia
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Tung, Nadine
- Other Affiliation: Division of Hematology Oncology, Beth Israel Deaconess Medical Center, Boston, USA
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Dorfling, Cecilia M
- Other Affiliation: Department of Genetics, University of Pretoria, Pretoria, South Africa
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van Rensburg, Elizabeth J
- Other Affiliation: Department of Genetics, University of Pretoria, Pretoria, South Africa
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Neuhausen, Susan L
- Other Affiliation: Department of Population Sciences, Beckman Research Institute, City of Hope, Duarte, USA
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Ding, Yuan C
- Other Affiliation: Department of Population Sciences, Beckman Research Institute, City of Hope, Duarte, USA
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Gerdes, Anne-Marie
- Other Affiliation: Department of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
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Ejlertsen, Bent
- Other Affiliation: Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
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Nielsen, Finn C
- Other Affiliation: Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
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Hansen, Thomas V
- Other Affiliation: Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
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Osorio, Ana
- Other Affiliation: Human Genetics Group, Spanish National Cancer Research Center (CNIO), Madrid, Spain; Center for Biomedical Network Research on Rare Diseases (CIBERER), Madrid, Spain
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Benitez, Javier
- Other Affiliation: Human Genetics Group, Spanish National Cancer Research Center (CNIO), Madrid, Spain; Center for Biomedical Network Research on Rare Diseases (CIBERER), Madrid, Spain
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Conejero, Raquel A
- Other Affiliation: Medical Oncology Service, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain
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Segota, Ena
- Other Affiliation: Holy Cross Hospital, Michael and Dianne Bienes Comprehensive Cancer Center, Fort Lauderdale, USA; Clinical Cancer Genetics Community Research Network, City of Hope, Duarte, USA
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Weitzel, Jeffrey N
- Other Affiliation: Division of Clinical Cancer Genetics, City of Hope (for the Clinical Cancer Genetics Community Research Network), City of Hope, Duarte, USA
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Thelander, Margo
- Other Affiliation: John Muir Medical Center, Walnut Creek, CA, USA; c/o Clinical Cancer Genetics Community Research Network, City of Hope, Duarte, USA
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Peterlongo, Paolo
- Other Affiliation: Istituto FIRC di Oncologia Molecolare (IFOM), Milan, Italy
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Radice, Paolo
- Other Affiliation: Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Istituto Nazionale dei Tumori (INT), Milan, Italy
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Pensotti, Valeria
- Other Affiliation: Division of Clinical Cancer Genetics, City of Hope (for the Clinical Cancer Genetics Community Research Network), City of Hope, Duarte, USA; Cogentech Cancer Genetic Test Laboratory, Milan, Italy
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Dolcetti, Riccardo
- Other Affiliation: Cancer Bioimmunotherapy Unit, Centro di Riferimento Oncologico (CRO), Aviano, Italy
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Bonanni, Bernardo
- Other Affiliation: Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, Italy
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Peissel, Bernard
- Other Affiliation: Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Istituto Nazionale dei Tumori (INT), Milan, Italy
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Zaffaroni, Daniela
- Other Affiliation: Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Istituto Nazionale dei Tumori (INT), Milan, Italy
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Scuvera, Giulietta
- Other Affiliation: Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Istituto Nazionale dei Tumori (INT), Milan, Italy
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Manoukian, Siranoush
- Other Affiliation: Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Istituto Nazionale dei Tumori (INT), Milan, Italy
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Varesco, Liliana
- Other Affiliation: Unit of Hereditary Cancer, Department of Epidemiology, Prevention and Special Functions, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Azienda Ospedaliera Universitaria “San Martino” di Genova, IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
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Capone, Gabriele L
- Other Affiliation: FiorGen Foundation for Pharmacogenomics, Sesto Fiorentino, Italy; Unit of Medical Genetics, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy
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Papi, Laura
- Other Affiliation: Unit of Medical Genetics, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy
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Ottini, Laura
- Other Affiliation: Department of Molecular Medicine, Sapienza University, Rome, Italy
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Yannoukakos, Drakoulis
- Other Affiliation: Department of Medical Oncology, Papageorgiou Hospital, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece
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Konstantopoulou, Irene
- Other Affiliation: Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research “Demokritos”, Athens, Greece
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Garber, Judy
- Other Affiliation: Dana-Farber Cancer Institute, Boston, USA
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Hamann, Ute
- Other Affiliation: Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany
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Donaldson, Alan
- Other Affiliation: Clinical Genetics Department, St Michael’s Hospital, Bristol, UK
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Brady, Angela
- Other Affiliation: North West Thames Regional Genetics Service, Kennedy-Galton Centre, Harrow, UK
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Brewer, Carole
- Other Affiliation: Department of Clinical Genetics, Royal Devon & Exeter Hospital, Exeter, UK
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Foo, Claire
- Other Affiliation: Merseyside and Cheshire Clinical Genetics Service, Liverpool Women’s NHS Foundation Trust, Liverpool, UK
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Evans, D Gareth
- Other Affiliation: Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK
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Frost, Debra
- Other Affiliation: Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge, UK
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Eccles, Diana
- Other Affiliation: Faculty of Medicine, University of Southampton, Southampton University Hospitals NHS Trust, Southampton, UK
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Douglas, Fiona
- Other Affiliation: Institute of Human Genetics, Northern Genetic Service, International Centre for Life, Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, UK
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Cook, Jackie
- Other Affiliation: Sheffield Clinical Genetics Service, Sheffield Children’s Hospital, Sheffield, UK
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Adlard, Julian
- Other Affiliation: Yorkshire Regional Genetics Service, Leeds Teaching Hospitals NHS Trust, Old Medical School, Leeds General Infirmary, Leeds, UK
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Barwell, Julian
- Other Affiliation: Leicestershire Clinical Genetics Service, Department of Clinical Genetics, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester, UK
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Walker, Lisa
- Other Affiliation: Oxford Regional Genetics Service, Churchill Hospital, Oxford, UK
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Izatt, Louise
- Other Affiliation: Clinical Genetics Service, Guy’s and St Thomas’ NHS Foundation Trust, London, UK
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Side, Lucy E
- Other Affiliation: North East Thames Regional Genetics Service, Great Ormond Street Hospital for Children NHS Trust, London, UK
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Kennedy, M J
- Other Affiliation: North East Thames Regional Genetics Service, Great Ormond Street Hospital for Children NHS Trust, London, UK; Academic Unit of Clinical and Molecular Oncology, Trinity College Dublin, College Green, Dublin 2, Ireland; Medical Oncology Service, St James’s Hospital, Dublin 8, Ireland
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Tischkowitz, Marc
- Other Affiliation: Department of Clinical Genetics, East Anglian Regional Genetics Service, Addenbrooke’s Hospital, Level 6, Addenbrooke’s Treatment Centre, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
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Rogers, Mark T
- Other Affiliation: All Wales Medical Genetics Services, University Hospital of Wales, Cardiff, UK
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Porteous, Mary E
- Other Affiliation: South East Scotland Regional Genetic Service, Western General Hospital, Edinburgh, UK
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Morrison, Patrick J
- Other Affiliation: Centre for Cancer Research & Cell Biology, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University Belfast, Belfast, UK; Department of Medical Genetics, Belfast Health and Social Care Trust, Belfast City Hospital, Belfast, UK
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Platte, Radka
- Other Affiliation: Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge, UK
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Eeles, Ros
- Other Affiliation: Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, UK
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Davidson, Rosemarie
- Other Affiliation: Ferguson-Smith Centre for Clinical Genetics, Yorkhill Hospitals, Glasgow, UK
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Hodgson, Shirley
- Other Affiliation: South West Thames Regional Genetics Service, Department of Medical Genetics, St George’s University of London, London, UK
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Cole, Trevor
- Other Affiliation: West Midlands Regional Genetics Service, Birmingham Women’s Hospital Healthcare NHS Trust, Birmingham, UK
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Godwin, Andrew K
- Other Affiliation: Department of Pathology & Laboratory Medicine, University of Kansas Medical Center, Kansas City, USA
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Isaacs, Claudine
- Other Affiliation: Lombardi Comprehensive Cancer Center, MedStar Georgetown University Hospital, Washington, USA
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Claes, Kathleen
- Other Affiliation: Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium
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De Leeneer, Kim
- Other Affiliation: Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium
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Meindl, Alfons
- Other Affiliation: Division of Tumor Genetics, Department of Gynaecology and Obstetrics, University Hospital Klinikum Rechts der Isar, Technische Universität München, Munich, Germany
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Gehrig, Andrea
- Other Affiliation: Center of Familial Breast and Ovarian Cancer, Department of Medical Genetics, Institut für Humangenetik, Biozentrum, Universität Würzburg, Am Hubland, Würzburg, Germany
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Wappenschmidt, Barbara
- Other Affiliation: Center for Hereditary Breast and Ovarian Cancer, Medical Faculty, Center for Integrated Oncology (CIO) Cancer Center Cologne, University Hospital Cologne, Cologne, Germany; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany
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Sutter, Christian
- Other Affiliation: Department of Human Genetics, Institute of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany
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Engel, Christoph
- Other Affiliation: Institute for Medical Informatics, Statistics and Epidemiology, Medical Faculty, University of Leipzig, Leipzig, Germany
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Niederacher, Dieter
- Other Affiliation: Department of Gynaecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany
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Steinemann, Doris
- Other Affiliation: Institute of Cell and Molecular Pathology, Centre for Pathology and Forensic and Genetic Medicine, Hannover Medical School, Hannover, Germany
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Plendl, Hansjoerg
- Other Affiliation: Institute of Human Genetics, University Medical Center Schleswig-Holstein, Kiel, Germany
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Kast, Karin
- Other Affiliation: Department of Gynecology and Obstetrics, University Hospital Carl Gustav Carus of Dresden, Technical University Dresden, Dresden, Germany
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Rhiem, Kerstin
- Other Affiliation: Center for Hereditary Breast and Ovarian Cancer, Medical Faculty, Center for Integrated Oncology (CIO) Cancer Center Cologne, University Hospital Cologne, Cologne, Germany; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany
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Ditsch, Nina
- Other Affiliation: Division of Tumor Genetics, Department of Gynaecology and Obstetrics, University Hospital Klinikum Rechts der Isar, Technische Universität München, Munich, Germany
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Arnold, Norbert
- Other Affiliation: Department of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, Kiel, Germany
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Varon-Mateeva, Raymonda
- Other Affiliation: Institute of Medical Genetics and Human Genetics, Campus Virchow-Klinikum, Charité Berlin – Universtitätsmedizin Berlin, Berlin, Germany
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Schmutzler, Rita K
- Other Affiliation: Center for Hereditary Breast and Ovarian Cancer, Medical Faculty, Center for Integrated Oncology (CIO) Cancer Center Cologne, University Hospital Cologne, Cologne, Germany; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany; German Consortium of Hereditary Breast and Ovarian Cancer (GC-HBOC), Cologne, Germany
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Preisler-Adams, Sabine
- Other Affiliation: Institute of Human Genetics, University Hospital Münster, Münster, Germany
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Markov, Nadja B
- Other Affiliation: Institute of Human Genetics, University Hospital Münster, Münster, Germany
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Wang-Gohrke, Shan
- Other Affiliation: Department of Gynecology and Obstetrics, University Hospital Ulm, Ulm, Germany
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de Pauw, Antoine
- Other Affiliation: Department of Tumour Biology, Institut Curie, Paris, France
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Lefol, Cédrick
- Other Affiliation: Department of Tumour Biology, Institut Curie, Paris, France
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Lasset, Christine
- Other Affiliation: UMR CNRS 5558, Laboratoire de Biométrie et Biologie Évolutive (LBBE), “Biométrie et Biologie Évolutive”, Université Claude Bernard Lyon 1, Bâtiment Grégor Mendel, Villeurbanne, France; Unité de Prévention et d’Épidémiologie Génétique, Centre Léon Bérard, Lyon, France
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Leroux, Dominique
- Other Affiliation: Génétique Clinique, Centre Hospitalier Universitaire de Grenoble, Grenoble, France; Institut Albert Bonniot – Inserm U823, Université Joseph Fourier, La Tronche, France
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Rouleau, Etienne
- Other Affiliation: Laboratoire d’Oncogénétique, Hôpital René Huguenin, Institut Curie, Saint-Cloud, France
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Damiola, Francesca
- Other Affiliation: INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France
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Dreyfus, Hélène
- Other Affiliation: Génétique Clinique, Centre Hospitalier Universitaire de Grenoble, Grenoble, France; Institut Albert Bonniot – Inserm U823, Université Joseph Fourier, La Tronche, Franc
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Barjhoux, Laure
- Other Affiliation: INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France
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Golmard, Lisa
- Other Affiliation: Department of Tumour Biology, Institut Curie, Paris, France
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Uhrhammer, Nancy
- Other Affiliation: Département d’Oncogénétique, Centre Jean Perrin, Université de Clermont-Ferrand, Clermont-Ferrand, France
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Bonadona, Valérie
- Other Affiliation: UMR CNRS 5558, Laboratoire de Biométrie et Biologie Évolutive (LBBE), “Biométrie et Biologie Évolutive”, Université Claude Bernard Lyon 1, Bâtiment Grégor Mendel, Villeurbanne, France; Unité de Prévention et d’Épidémiologie Génétique, Centre Léon Bérard, Lyon, France
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Sornin, Valérie
- Other Affiliation: INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France
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Bignon, Yves-Jean
- Other Affiliation: Département d’Oncogénétique, Centre Jean Perrin, Université de Clermont-Ferrand, Clermont-Ferrand, France
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Carter, Jonathan
- Other Affiliation: Gynaecological Oncology, Sydney Cancer Centre, Royal Prince Alfred Hospital and University of Sydney, Camperdown, Australia
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Van Le, Linda
- Affiliation: School of Medicine, Department of Obstetrics and Gynecology
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Piedmonte, Marion
- Other Affiliation: Gynecologic Oncology Group Statistical and Data Center, Roswell Park Cancer Institute, Buffalo, USA
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DiSilvestro, Paul A
- Other Affiliation: Women & Infants Hospital, Providence, USA
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de la Hoya, Miguel
- Other Affiliation: Molecular Oncology Laboratory, Health Research Institute of the San Carlos Clinical Hospital (IdISSC), Madrid, Spain
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Caldes, Trinidad
- Other Affiliation: Molecular Oncology Laboratory, Health Research Institute of the San Carlos Clinical Hospital (IdISSC), Madrid, Spain
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Nevanlinna, Heli
- Other Affiliation: Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Biomedicum Helsinki, Helsinki, Finland
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Aittomäki, Kristiina
- Other Affiliation: Department of Clinical Genetics, Helsinki University Central Hospital, Biomedicum Helsinki 1, Helsinki, Finland
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Jager, Agnes
- Other Affiliation: Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, the Netherlands
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van den Ouweland, Ans M
- Other Affiliation: Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, the Netherlands
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Kets, Carolien M
- Other Affiliation: Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands
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Aalfs, Cora M
- Other Affiliation: Department of Clinical Genetics, Academic Medical Center, Amsterdam, the Netherlands
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van Leeuwen, Flora E
- Other Affiliation: Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands
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Hogervorst, Frans B
- Other Affiliation: Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, the Netherlands
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Meijers-Heijboer, Hanne E
- Other Affiliation: Department of Clinical Genetics, VU University Medical Center Amsterdam, Amsterdam, the Netherlands
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Oosterwijk, Jan C
- Other Affiliation: Department of Genetics, University Medical Center, Groningen University, Groningen, the Netherlands
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van Roozendaal, Kees E
- Other Affiliation: Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, the Netherlands
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Rookus, Matti A
- Other Affiliation: Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands
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Devilee, Peter
- Other Affiliation: Department of Human Genetics, Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands; Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands
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van der Luijt, Rob B
- Other Affiliation: Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands
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Olah, Edith
- Other Affiliation: Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary
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Diez, Orland
- Other Affiliation: Oncogenetics Group, Vall d’Hebron Institute of Oncology (VHIO), University Hospital Vall d’Hebron, Vall d’Hebron Research Institute (VHIR) and Universitat Autònoma de Barcelona, Barcelona, Spain
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Teulé, Alex
- Other Affiliation: Genetic Counseling Unit, Hereditary Cancer Program, Institut d’Investigació Biomèdica de Bellvitge (IDIBELL)-Catalan Institute of Oncology, Hospital Duran i Reynals, Barcelona, Spain
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Lazaro, Conxi
- Other Affiliation: Molecular Diagnostic Unit, Hereditary Cancer Program, Institut d’Investigació Biomèdica de Bellvitge (IDIBELL)-Catalan Institute of Oncology, Hospital Duran i Reynals, Barcelona, Spain
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Blanco, Ignacio
- Other Affiliation: Genetic Counseling Unit, Hereditary Cancer Program, Institut d’Investigació Biomèdica de Bellvitge (IDIBELL)-Catalan Institute of Oncology, Hospital Duran i Reynals, Barcelona, Spain
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Del Valle, Jesús
- Other Affiliation: Molecular Diagnostic Unit, Hereditary Cancer Program, Institut d’Investigació Biomèdica de Bellvitge (IDIBELL)-Catalan Institute of Oncology, Hospital Duran i Reynals, Barcelona, Spain
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Jakubowska, Anna
- Other Affiliation: Department of Genetics and Pathomorphology, Faculty of Medicine and Dentistry, Pomeranian Medical University, Szczecin, Poland
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Sukiennicki, Grzegorz
- Other Affiliation: Department of Genetics and Pathomorphology, Faculty of Medicine and Dentistry, Pomeranian Medical University, Szczecin, Poland
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Gronwald, Jacek
- Other Affiliation: Department of Genetics and Pathomorphology, Faculty of Medicine and Dentistry, Pomeranian Medical University, Szczecin, Poland
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Lubinski, Jan
- Other Affiliation: Department of Genetics and Pathomorphology, Faculty of Medicine and Dentistry, Pomeranian Medical University, Szczecin, Poland
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Durda, Katarzyna
- Other Affiliation: Department of Genetics and Pathomorphology, Faculty of Medicine and Dentistry, Pomeranian Medical University, Szczecin, Poland
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Jaworska-Bieniek, Katarzyna
- Other Affiliation: Department of Genetics and Pathomorphology, Faculty of Medicine and Dentistry, Pomeranian Medical University, Szczecin, Poland
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Agnarsson, Bjarni A
- Other Affiliation: Landspítali National University Hospital of Iceland and Faculty of Medicine, School of Health Sciences, University of Iceland School of Medicine, Reykjavik, Iceland
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Maugard, Christine
- Other Affiliation: Laboratoire de diagnostic génétique et Service d’Onco-hématologie, Les Hopitaux Universitaire de Strasbourg, Nouvel Hôpital Civil, Strasbourg, France
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Amadori, Alberto
- Other Affiliation: Department of Surgical Sciences, Oncology and Gastroenterology, Padua University, Clinical Surgery II, Padua, Italy; Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto (IOV) – Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Padua, Italy
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Montagna, Marco
- Other Affiliation: Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto (IOV) – Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Padua, Italy
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Teixeira, Manuel R
- Other Affiliation: Department of Genetics, Portuguese Oncology Institute (IPO-PORTO), Porto, Portugal; Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto, Porto, Portugal
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Spurdle, Amanda B
- Other Affiliation: Department of Genetics and Computational Biology, QIMR Berghofer, Brisbane, Australia
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Foulkes, William
- Other Affiliation: Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montreal, Canada
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Olswold, Curtis
- Other Affiliation: Department of Health Sciences Research, Mayo Clinic, Rochester, USA
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Lindor, Noralane M
- Other Affiliation: Department of Health Sciences Research, Mayo Clinic, Scottsdale, USA
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Pankratz, Vernon S
- Other Affiliation: Department of Health Sciences Research, Mayo Clinic, Rochester, USA
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Szabo, Csilla I
- Other Affiliation: National Human Genome Research Institute, National Institutes of Health, Bethesda, USA
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Lincoln, Anne
- Other Affiliation: Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, USA
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Jacobs, Lauren
- Other Affiliation: Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, USA
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Corines, Marina
- Other Affiliation: Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, USA
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Robson, Mark
- Other Affiliation: Clinical Genetics Research Laboratory, Memorial Sloan Kettering Cancer Center, New York, USA
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Vijai, Joseph
- Other Affiliation: Clinical Genetics Research Laboratory, Memorial Sloan Kettering Cancer Center, New York, USA
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Berger, Andreas
- Other Affiliation: Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Universitätsklinik für Frauenheilkunde, AKH – Wien, Vienna, Austria
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Fink-Retter, Anneliese
- Other Affiliation: Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Universitätsklinik für Frauenheilkunde, AKH – Wien, Vienna, Austria
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Singer, Christian F
- Other Affiliation: Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Universitätsklinik für Frauenheilkunde, AKH – Wien, Vienna, Austria
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Rappaport, Christine
- Other Affiliation: Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Universitätsklinik für Frauenheilkunde, AKH – Wien, Vienna, Austria
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Kaulich, Daphne G
- Other Affiliation: Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Universitätsklinik für Frauenheilkunde, AKH – Wien, Vienna, Austria
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Pfeiler, Georg
- Other Affiliation: Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Universitätsklinik für Frauenheilkunde, AKH – Wien, Vienna, Austria
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Tea, Muy-Kheng
- Other Affiliation: Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Universitätsklinik für Frauenheilkunde, AKH – Wien, Vienna, Austria
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Greene, Mark H
- Other Affiliation: Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, USA
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Mai, Phuong L
- Other Affiliation: Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, USA
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Rennert, Gad
- Other Affiliation: Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, Italy; National Israeli Cancer Control Center and Department of Community Medicine and Epidemiology, Clalit Health Services Carmel Medical Center, Haifa, Israel; Ruth and Bruce Rappaport Faculty of Medicine, Technion – Israel Institute of Technology, Haifa, Israel
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Imyanitov, Evgeny N
- Other Affiliation: NN Petrov Institute of Oncology, Pesochny, Russia
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Mulligan, Anna M
- Other Affiliation: Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada; Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael’s Hospital, Toronto, Canada
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Glendon, Gord
- Other Affiliation: Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, Canada; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital Joseph and Wolf Lebovic Health Complex, Toronto, Canada
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Andrulis, Irene L
- Other Affiliation: Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital Joseph and Wolf Lebovic Health Complex, Toronto, Canada; Department of Molecular Genetics, University of Toronto, Toronto, Canada
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Tchatchou, Sandrine
- Other Affiliation: Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital Joseph and Wolf Lebovic Health Complex, Toronto, Canada
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Toland, Amanda E
- Other Affiliation: Department of Human Cancer Genetics, 1093 Biomedical Research Tower, Columbus, USA; Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, USA; Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Wexner Medical Center, Columbus, USA; The Ohio State University Comprehensive Cancer Center – Arthur G James Cancer Hospital and Richard J Solove Research Institute (OSUCCC – James), Columbus, USA
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Pedersen, Inge S
- Other Affiliation: Section of Molecular Diagnostics, Department of Biochemistry, Aalborg University Hospital, Aalborg, Denmark
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Thomassen, Mads
- Other Affiliation: Department of Clinical Genetics, Odense University Hospital, Odense C, Denmark
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Kruse, Torben A
- Other Affiliation: Department of Clinical Genetics, Odense University Hospital, Odense C, Denmark
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Jensen, Uffe B
- Other Affiliation: Department of Clinical Genetics, Aarhus University Hospital, Aarhus N, Denmark
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Caligo, Maria A
- Other Affiliation: Laboratorio di Genetica Oncologica, Divisione di Anatomia Patologica e di Diagnostica Molecolare ed Ultrastrutturale, Azienda Ospedaliero Universitaria Pisana – Ospedale S Chiara, Pisa, Italy
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Friedman, Eitan
- Other Affiliation: Sheba Laboratory of Molecular Genetics, The Danek Gertner Institute of Human Genetics, Sheba Medical Center, Tel Aviv, Israel
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Zidan, Jamal
- Other Affiliation: Institute of Oncology, Rivka Ziv Medical Center, Safed, Israel
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Laitman, Yael
- Other Affiliation: Sheba Laboratory of Molecular Genetics, The Danek Gertner Institute of Human Genetics, Sheba Medical Center, Tel Aviv, Israel
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Lindblom, Annika
- Other Affiliation: Department of Cancer Genetics, Karolinska University Hospital, Stockholm, Sweden
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Melin, Beatrice
- Other Affiliation: Oncology, Department of Radiation Sciences, Umeå University, Umeå, Sweden
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Arver, Brita
- Other Affiliation: Department of Oncology-Pathology, Karolinska University Hospital, K7, Ärftlighetsmottagningen, Radiumhemmet, Stockholm, Sweden
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Loman, Niklas
- Other Affiliation: Division of Oncology and Pathology, Department of Clinical Sciences, Lund University Hospital, Lund, Sweden
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Rosenquist, Richard
- Other Affiliation: Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
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Olopade, Olufunmilayo I
- Other Affiliation: Center for Clinical Cancer Genetics and Global Health, The University of Chicago, Chicago, USA
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Nussbaum, Robert L
- Other Affiliation: Department of Medicine and Genetics, University of California, San Francisco, USA
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Ramus, Susan J
- Other Affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, USA
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Nathanson, Katherine L
- Other Affiliation: Department of Medicine, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA
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Domchek, Susan M
- Other Affiliation: Department of Medicine, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA
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Rebbeck, Timothy R
- Other Affiliation: Department of Epidemiology and Biostatistics, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA
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Arun, Banu K
- Other Affiliation: Division of Cancer Medicine, Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
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Mitchell, Gillian
- Other Affiliation: Sir Peter MacCallum Department of Oncology, Familial Cancer Centre, Peter MacCallum Cancer Centre, East Melbourne, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Australia
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Karlan, Beth Y
- Other Affiliation: Women’s Cancer Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, USA
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Lester, Jenny
- Other Affiliation: Women’s Cancer Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, USA
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Orsulic, Sandra
- Other Affiliation: Women’s Cancer Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, USA
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Stoppa-Lyonnet, Dominique
- Other Affiliation: Department of Tumour Biology, Institut Curie, Paris, France; Service de génétique oncologique, Institut Curie, Inserm U830, Paris, France; Faculté de Médecine, Université Paris Descartes, Paris, France
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Thomas, Gilles
- Other Affiliation: Génétique médicale, Faculté de Médecine Lyon Est, Université Claude Bernard Lyon 1, Lyon, France; Institut National du Cancer (INCa), La Fondation Synergie Lyon Cancer, Centre Léon Bérard, Lyon, France
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Simard, Jacques
- Other Affiliation: Centre de recherche du Centre hospitalier universitaire de Québec, Laval University, Charlesbourg, Canada
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Couch, Fergus J
- Other Affiliation: Department of Health Sciences Research, Mayo Clinic, Rochester, USA; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, USA
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Offit, Kenneth
- Other Affiliation: Clinical Genetics Research Laboratory, Memorial Sloan Kettering Cancer Center, New York, USA
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Easton, Douglas F
- Other Affiliation: Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
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Chenevix-Trench, Georgia
- Other Affiliation: Department of Genetics and Computational Biology, QIMR Berghofer, Brisbane, Australia
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Antoniou, Antonis C
- Other Affiliation: Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
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Mazoyer, Sylvie
- Other Affiliation: INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France; Université de Lyon, Lyon, France; Université Lyon 1, Villeurbanne, France
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Phelan, Catherine M
- Other Affiliation: Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, USA
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Sinilnikova, Olga M
- Other Affiliation: INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France; Université de Lyon, Lyon, France; Université Lyon 1, Villeurbanne, France; Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon – Centre Léon Bérard, Lyon, France
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Cox, David G
- Other Affiliation: INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France; Université de Lyon, Lyon, France; Université Lyon 1, Villeurbanne, France
- Abstract
- Introduction Individuals carrying pathogenic mutations in the BRCA1 and BRCA2 genes have a high lifetime risk of breast cancer. BRCA1 and BRCA2 are involved in DNA double-strand break repair, DNA alterations that can be caused by exposure to reactive oxygen species, a main source of which are mitochondria. Mitochondrial genome variations affect electron transport chain efficiency and reactive oxygen species production. Individuals with different mitochondrial haplogroups differ in their metabolism and sensitivity to oxidative stress. Variability in mitochondrial genetic background can alter reactive oxygen species production, leading to cancer risk. In the present study, we tested the hypothesis that mitochondrial haplogroups modify breast cancer risk in BRCA1/2 mutation carriers. Methods We genotyped 22,214 (11,421 affected, 10,793 unaffected) mutation carriers belonging to the Consortium of Investigators of Modifiers of BRCA1/2 for 129 mitochondrial polymorphisms using the iCOGS array. Haplogroup inference and association detection were performed using a phylogenetic approach. ALTree was applied to explore the reference mitochondrial evolutionary tree and detect subclades enriched in affected or unaffected individuals. Results We discovered that subclade T1a1 was depleted in affected BRCA2 mutation carriers compared with the rest of clade T (hazard ratio (HR) = 0.55; 95% confidence interval (CI), 0.34 to 0.88; P = 0.01). Compared with the most frequent haplogroup in the general population (that is, H and T clades), the T1a1 haplogroup has a HR of 0.62 (95% CI, 0.40 to 0.95; P = 0.03). We also identified three potential susceptibility loci, including G13708A/rs28359178, which has demonstrated an inverse association with familial breast cancer risk. Conclusions This study illustrates how original approaches such as the phylogeny-based method we used can empower classical molecular epidemiological studies aimed at identifying association or risk modification effects.
- Date of publication
- April 25, 2015
- DOI
- Identifier
- Resource type
- Article
- Rights statement
- In Copyright
- Rights holder
- Blein et al.; licensee BioMed Central.
- Journal title
- Breast Cancer Research
- Journal volume
- 17
- Journal issue
- 1
- Page start
- 61
- Language
- English
- Bibliographic citation
- Breast Cancer Research. 2015 Apr 25;17(1):61
- Publisher
- BioMed Central
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- Parents:
This work has no parents.
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