A systematic review of antibody mediated immunity to coronaviruses: kinetics, correlates of protection, and association with severity

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  • Huang, A.T
    • Other Affiliation: Department of Biology, University of Florida, Gainesville, FL, United States
  • Garcia-Carreras, B
    • Other Affiliation: Department of Biology, University of Florida, Gainesville, FL, United States
  • Hitchings, M.D.T
    • Other Affiliation: Department of Biology, University of Florida, Gainesville, FL, United States
  • Yang, B
    • Other Affiliation: Department of Biology, University of Florida, Gainesville, FL, United States
  • Katzelnick, L.C
    • Other Affiliation: Department of Biology, University of Florida, Gainesville, FL, United States
  • Rattigan, S.M
    • Other Affiliation: Department of Biology, University of Florida, Gainesville, FL, United States
  • Borgert, B.A
    • Other Affiliation: Department of Biology, University of Florida, Gainesville, FL, United States
  • Moreno, C.A
    • Other Affiliation: Department of Biology, University of Florida, Gainesville, FL, United States
  • Solomon, B.D
    • Other Affiliation: National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, United States
  • Trimmer-Smith, L
    • Other Affiliation: Department of Biology, University of Florida, Gainesville, FL, United States
  • Etienne, V
    • Other Affiliation: Emerging Pathogens Institute, University of Florida, Gainesville, FL, United States
  • Rodriguez-Barraquer, I
    • Other Affiliation: Division of HIV, ID, and Global Medicine, University of California, San Francisco, CA, United States
  • Lessler, J
    • Affiliation: Gillings School of Global Public Health, Department of Epidemiology
    • Other Affiliation: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States
  • Salje, H
    • Other Affiliation: Department of Biology, University of Florida, Gainesville, FL, United States
  • Burke, D.S
    • Other Affiliation: Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, United States
  • Wesolowski, A
    • Other Affiliation: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States
  • Cummings, D.A.T
    • Other Affiliation: Department of Biology, University of Florida, Gainesville, FL, United States
Abstract
  • Many public health responses and modeled scenarios for COVID-19 outbreaks caused by SARS-CoV-2 assume that infection results in an immune response that protects individuals from future infections or illness for some amount of time. The presence or absence of protective immunity due to infection or vaccination (when available) will affect future transmission and illness severity. Here, we review the scientific literature on antibody immunity to coronaviruses, including SARS-CoV-2 as well as the related SARS-CoV, MERS-CoV and endemic human coronaviruses (HCoVs). We reviewed 2,452 abstracts and identified 491 manuscripts relevant to 5 areas of focus: 1) antibody kinetics, 2) correlates of protection, 3) immunopathogenesis, 4) antigenic diversity and cross-reactivity, and 5) population seroprevalence. While further studies of SARS-CoV-2 are necessary to determine immune responses, evidence from other coronaviruses can provide clues and guide future research.
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Resource type
  • Article
License
  • Attribution 4.0 International
Journal title
  • Nature Communications
Journal volume
  • 11
Journal issue
  • 1
Language
  • English
Version
  • Publisher
Funder
  • U.S. National Library of Medicine, NLM: DP2LM013102
  • National Institutes of Health, NIH
  • Burroughs Wellcome Fund, BWF
  • National Human Genome Research Institute, NHGRI
  • 1021212
  • National Institute of Allergy and Infectious Diseases, NIAID: R01AI114703
ISSN
  • 2041-1723
Publisher
  • Nature Research

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