New Metrics for Evaluating Viral Respiratory Pathogenesis
Public Deposited- Creator
-
Menachery, Vineet D.
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
-
Gralinski, Lisa E.
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
-
Baric, Ralph S.
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
-
Ferris, Martin T.
- Affiliation: School of Medicine, Department of Genetics
- Abstract
- Viral pathogenesis studies in mice have relied on markers of severe systemic disease, rather than clinically relevant measures, to evaluate respiratory virus infection; thus confounding connections to human disease. Here, whole-body plethysmography was used to directly measure changes in pulmonary function during two respiratory viral infections. This methodology closely tracked with traditional pathogenesis metrics, distinguished both virusand dose-specific responses, and identified long-term respiratory changes following both SARS-CoV and Influenza A Virus infection. Together, the work highlights the utility of examining respiratory function following infection in order to fully understand viral pathogenesis.
- Date of publication
- 2015
- DOI
- Identifier
- Resource type
- Article
- Rights statement
- In Copyright
- License
- Attribution 3.0 United States
- Journal title
- PLoS ONE
- Journal volume
- 10
- Journal issue
- 6
- Language
- English
Relations
- Parents:
- In Collection:
This work has no parents.
Items
| Thumbnail | Title | Date Uploaded | Visibility | Actions |
|---|---|---|---|---|
|
|
journal.pone.0131451.PDF | 2020-06-19 | Public | Download |