Vaccine-mediated protection against Merbecovirus and Sarbecovirus challenge in mice
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Martinez, David R, et al. Vaccine-mediated Protection Against Merbecovirus and Sarbecovirus Challenge In Mice. Cell Press, 2023. https://doi.org/10.17615/x4w7-2n32APA
Martinez, D., Schäfer, A., Gavitt, T., Mallory, M., Lee, E., Catanzaro, N., Chen, H., Gully, K., Scobey, T., Korategere, P., Brown, A., Smith, L., Parks, R., Barr, M., Newman, A., Bowman, C., Powers, J., Soderblom, E., Mansouri, K., Edwards, R., Baric, R., Haynes, B., & Saunders, K. (2023). Vaccine-mediated protection against Merbecovirus and Sarbecovirus challenge in mice. Cell Press. https://doi.org/10.17615/x4w7-2n32Chicago
Martinez, David R., Alexandra Schäfer, Tyler D Gavitt, Michael L Mallory, Esther Lee, Nicholas J Catanzaro, Haiyan Chen et al. 2023. Vaccine-Mediated Protection Against Merbecovirus and Sarbecovirus Challenge In Mice. Cell Press. https://doi.org/10.17615/x4w7-2n32- Creator
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Martinez, David R.
- Other Affiliation: Yale School of Medicine
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Schäfer, Alexandra
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
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Gavitt, Tyler D.
- Other Affiliation: Duke University School of Medicine
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Mallory, Michael L.
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
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Lee, Esther
- Other Affiliation: Duke University School of Medicine
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Catanzaro, Nicholas J.
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
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Chen, Haiyan
- Other Affiliation: Duke University School of Medicine
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Gully, Kendra
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
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Scobey, Trevor
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
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Korategere, Pooja
- Other Affiliation: Duke University School of Medicine
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Brown, Alecia
- Other Affiliation: Duke University School of Medicine
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Smith, Lena
- Other Affiliation: Duke University School of Medicine
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Parks, Robert
- Other Affiliation: Duke University School of Medicine
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Barr, Maggie
- Other Affiliation: Duke University School of Medicine
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Newman, Amanda
- Other Affiliation: Duke University School of Medicine
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Bowman, Cindy
- Other Affiliation: Duke University School of Medicine
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Powers, John M.
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
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Soderblom, Erik J.
- Other Affiliation: Duke University School of Medicine
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Mansouri, Katayoun
- Other Affiliation: Duke University School of Medicine
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Edwards, Robert J.
- Other Affiliation: Duke University School of Medicine
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Baric, Ralph S.
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
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Haynes, Barton F.
- Other Affiliation: Duke University School of Medicine
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Saunders, Kevin O.
- Other Affiliation: Duke University School of Medicine
- Abstract
- The emergence of three highly pathogenic human coronaviruses-severe acute respiratory syndrome coronavirus (SARS-CoV) in 2003, Middle Eastern respiratory syndrome (MERS)-CoV in 2012, and SARS-CoV-2 in 2019-underlines the need to develop broadly active vaccines against the Merbecovirus and Sarbecovirus betacoronavirus subgenera. While SARS-CoV-2 vaccines protect against severe COVID-19, they do not protect against other sarbecoviruses or merbecoviruses. Here, we vaccinate mice with a trivalent sortase-conjugate nanoparticle (scNP) vaccine containing the SARS-CoV-2, RsSHC014, and MERS-CoV receptor-binding domains (RBDs), which elicited live-virus neutralizing antibody responses. The trivalent RBD scNP elicited serum neutralizing antibodies against bat zoonotic Wuhan Institute of Virology-1 (WIV-1)-CoV, SARS-CoV, SARS-CoV-2 BA.1, SARS-CoV-2 XBB.1.5, and MERS-CoV live viruses. The monovalent SARS-CoV-2 RBD scNP vaccine only protected against Sarbecovirus challenge, whereas the trivalent RBD scNP vaccine protected against both Merbecovirus and Sarbecovirus challenge in highly pathogenic and lethal mouse models. This study demonstrates proof of concept for a single pan-sarbecovirus/pan-merbecovirus vaccine that protects against three highly pathogenic human coronaviruses spanning two betacoronavirus subgenera.
- Date of publication
- 2023
- Keyword
- DOI
- Identifier
- Resource type
- Article
- License
- Attribution-NonCommercial-NoDerivs 4.0 International
- Journal title
- Cell Reports
- Page start
- 113248
- Language
- English
- Version
- Postprint
- ISSN
- 2211-1247
- Publisher
- Cell Press
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