Diet and toenail arsenic concentrations in a New Hampshire population with arsenic-containing water Public Deposited

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Creator
  • Punshon, Tracy
    • Other Affiliation: Department of Biological Sciences, Dartmouth College, Hanover, NH, USA
  • Cottingham, Kathryn L
    • Other Affiliation: Department of Biological Sciences, Dartmouth College, Hanover, NH, USA
  • Folt, Carol L
    • Other Affiliation: Department of Biological Sciences, Dartmouth College, Hanover, NH, USA
  • Zens, M
    • Other Affiliation: Section of Biostatistics and Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA
  • Sayarath, Vicki
    • Other Affiliation: Section of Biostatistics and Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA
  • Morris, J
    • Other Affiliation: Section of Biostatistics and Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA
  • Karimi, Roxanne
    • Other Affiliation: Department of Biological Sciences, Dartmouth College, Hanover, NH, USA; School of Marine and Atmospheric Sciences, Stony Brook University, Stony Brook, NY, USA
  • Karagas, Margaret R
    • Other Affiliation: Section of Biostatistics and Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA
  • Gruber, Joann F
    • Affiliation: Gillings School of Global Public Health, Department of Epidemiology
    • Other Affiliation: Department of Biological Sciences, Dartmouth College, Hanover, NH, USA
Abstract
  • Abstract Background Limited data exist on the contribution of dietary sources of arsenic to an individual’s total exposure, particularly in populations with exposure via drinking water. Here, the association between diet and toenail arsenic concentrations (a long-term biomarker of exposure) was evaluated for individuals with measured household tap water arsenic. Foods known to be high in arsenic, including rice and seafood, were of particular interest. Methods Associations between toenail arsenic and consumption of 120 individual diet items were quantified using general linear models that also accounted for household tap water arsenic and potentially confounding factors (e.g., age, caloric intake, sex, smoking) (n = 852). As part of the analysis, we assessed whether associations between log-transformed toenail arsenic and each diet item differed between subjects with household drinking water arsenic concentrations <1 μg/L versus ≥1 μg/L. Results As expected, toenail arsenic concentrations increased with household water arsenic concentrations. Among the foods known to be high in arsenic, no clear relationship between toenail arsenic and rice consumption was detected, but there was a positive association with consumption of dark meat fish, a category that includes tuna steaks, mackerel, salmon, sardines, bluefish, and swordfish. Positive associations between toenail arsenic and consumption of white wine, beer, and Brussels sprouts were also observed; these and most other associations were not modified by exposure via water. However, consumption of two foods cooked in water, beans/lentils and cooked oatmeal, was more strongly related to toenail arsenic among those with arsenic-containing drinking water (≥1 μg/L). Conclusions This study suggests that diet can be an important contributor to total arsenic exposure in U.S. populations regardless of arsenic concentrations in drinking water. Thus, dietary exposure to arsenic in the US warrants consideration as a potential health risk.
Date of publication
Identifier
  • doi:10.1186/1475-2891-12-149
  • 24237880
Resource type
  • Article
Rights statement
  • In Copyright
Rights holder
  • Kathryn L Cottingham et al.; licensee BioMed Central Ltd.
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Journal title
  • Nutrition Journal
Journal volume
  • 12
Journal issue
  • 1
Page start
  • 149
Language
  • English
Is the article or chapter peer-reviewed?
  • Yes
ISSN
  • 1475-2891
Bibliographic citation
  • Nutrition Journal. 2013 Nov 16;12(1):149
Access
  • Open Access
Publisher
  • BioMed Central Ltd
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