Modulation of B-cell exosome proteins by gamma herpesvirus infection
Public Deposited- Creator
- Meckes, D. G.
- Gunawardena, H. P.
- Dekroon, R. M.
- Heaton, P. R.
- Edwards, R. H.
- Ozgur, S.
- Griffith, J. D.
- Damania, B.
- Raab-Traub, N.
- Abstract
- Exosomes are released from tumor cells at high levels, and multiple studies have determined that the secreted exosomes enter recipient cells and can affect their biologic and biochemical properties. In this study, the specific effects of the oncogenic herpesviruses, EBV and Kaposi sarcoma-associated virus, on the proteomes of B-cell exosomes were determined using global quantitative proteomics. The data indicate that the viruses greatly impact the protein content of exosomes with common and distinct changes induced by both viruses. It is likely that these alterations in exosome content modulate the tumor environment, potentially to enhance viral infection and promote tumorigenesis.
- Date of publication
- 2013
- Keyword
- DOI
- Identifier
- PMCID: PMC3732930
- Onescience id: aebd0eb88a8d8081058a668f409f22312509dcf4
- Publisher DOI: https://doi.org/10.1073/pnas.1303906110
- PMID: 23818640
- Resource type
- Article
- Rights statement
- In Copyright
- Journal title
- Proceedings of the National Academy of Sciences of the United States of America
- Journal volume
- 110
- Journal issue
- 31
- Page start
- E2925
- Page end
- E2933
- Language
- English
- ISSN
- 0744-2831
- 0027-8424
- 1091-6490
Relations
- Parents:
This work has no parents.
Items
| Thumbnail | Title | Date Uploaded | Visibility | Actions |
|---|---|---|---|---|
|
|
EuropePMC-PMC3732930.pdf | November 1, 2020 | Public | Download |