Association of sICAM-1 and MCP-1 with coronary artery calcification in families enriched for coronary heart disease or hypertension: the NHLBI Family Heart Study Public Deposited

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  • Bielinski, Suzette J
    • Other Affiliation: Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA
  • Kraja, Aldi T
    • Other Affiliation: Division of Statistical Genomics, Washington University School of Medicine, Saint Louis, MO, USA
  • Pankow, James S
    • Other Affiliation: Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA
  • Tang, Weihong
    • Other Affiliation: Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA
  • North, Kari
    • Affiliation: Gillings School of Global Public Health, Department of Epidemiology
  • Tracy, Russell P
    • Other Affiliation: Department of Pathology and Biochemistry, University of Vermont, Burlington, VT, USA
  • Carr, J Jeffrey
    • Other Affiliation: Department of Radiology, Wake Forest University School of Medicine, Winston-Salem, NC, USA
  • Hopkins, Paul N
    • Other Affiliation: Cardiovascular Genetics, University of Utah School of Medicine, Salt Lake City, UT, USA
  • Arnett, Donna K
    • Other Affiliation: Department of Epidemiology, School of Public Health, University of Alabama- Birmingham, Birmingham, AL, USA
  • Abstract Background: Data accumulated from mouse studies and in vitro studies of human arteries support the notion that soluble intercellular adhesion molecule-1 (sICAM-1) and monocyte chemoattractant protein-1 (MCP-1) play important roles in the inflammation process involved in atherosclerosis. However, at the population level, the utility of sICAM-1 and MCP-1 as biomarkers for subclinical atherosclerosis is less clear. In the follow-up exam of the NHLBI Family Heart Study, we evaluated whether plasma levels of sICAM-1 and MCP-1 were associated with coronary artery calcification (CAC), a measure of the burden of coronary atherosclerosis. Methods: CAC was measured using the Agatston score with multidetector computed tomography. Information on CAC and MCP-1 was obtained in 2246 whites and 470 African Americans (mean age 55 years) without a history of coronary heart disease (CHD). Information on sICAM-1 was obtained for white participants only. Results: In whites, after adjustment for age and gender, the odds ratios (ORs) of CAC (CAC > 0) associated with the second, third, fourth, and fifth quintiles of sICAM-1 compared to the first quintile were 1.22 (95% confidence interval [CI]: 0.91–1.63), 1.15 (0.84–1.58), 1.49 (1.09–2.05), and 1.72 (1.26–2.36) (p = 0.0005 for trend test), respectively. The corresponding ORs for the second to fifth quintiles of MCP-1 were 1.26 (0.92–1.73), 0.99 (0.73–1.34), 1.42 (1.03–1.96), and 2.00 (1.43–2.79) (p < 0.0001 for trend test), respectively. In multivariable analysis that additionally adjusted for other CHD risk factors, the association of CAC with sICAM-1 and MCP-1 was attenuated and no longer statistically significant. In African Americans, the age and gender-adjusted ORs of CAC associated with the second and third tertiles of MCP-1 compared to the first tertile were 1.16 (0.64–2.08) and 1.25 (0.70–2.23) (p = 0.44 for trend test), respectively. This result did not change materially after additional adjustment for other CHD risk factors. Test of race interaction showed that the magnitude of association between MCP-1 and CAC did not differ significantly between African Americans and whites. Similar results were obtained when CAC ≥ 10 was analyzed as an outcome for both MCP-1 and sICAM-1. Conclusion: This study suggests that sICAM-1 and MCP-1 are biomarkers of coronary atherosclerotic burden and their association with CAC was mainly driven by established CHD risk factors.
Date of publication
  • 17963506
  • doi:10.1186/1471-2261-7-30
Resource type
  • Article
Rights statement
  • In Copyright
Rights holder
  • Weihong Tang et al.; licensee BioMed Central Ltd.
Journal title
  • BMC Cardiovascular Disorders
Journal volume
  • 7
Journal issue
  • 1
Page start
  • 30
  • English
Is the article or chapter peer-reviewed?
  • Yes
  • 1471-2261
Bibliographic citation
  • BMC Cardiovascular Disorders. 2007 Oct 26;7(1):30
  • Open Access
  • BioMed Central Ltd

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