The relationship between insulin resistance and surrogates of adiposity in children and adolescents Public Deposited

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Last Modified
  • March 22, 2019
Creator
  • Hawkins, Jessica Noelle Ziebell
    • Affiliation: College of Arts and Sciences, Department of Exercise and Sport Science
Abstract
  • This study investigated the relationship between insulin resistance (HOMA-IR>4.0) and six adiposity surrogates in children and adolescents: body mass index (BMI), BMI percentiles (BMI %), sum of skinfolds (SSF), waist circumference (WC), WC percentiles (WC %), and waist circumference to height ratio (WHtR). Step-wise multiple regression models for HOMA-IR, including age, sex, and ethnicity, found that SSF was the strongest surrogate for predicting insulin resistance (r2=0.298) with little influence from age, sex, and ethnicity. The weakest predictor was BMI % (r2=0.148) and was significantly influenced by age, sex, and ethnicity. Odds ratios were determined for risk of developing insulin resistance. These were highest for SSF compared to the other surrogates, with SSF >28 mm, increasing the risk of insulin resistance 9.2 times (CI=7.0-11.9). Thus, SSF appears to be the most independent surrogate to predict insulin resistance and BMI % the least independent surrogate.
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  • In Copyright
Advisor
  • McMurray, Robert G.
Degree granting institution
  • University of North Carolina at Chapel Hill
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  • Open access
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