The roles of Canoe (Cno) in the regulation of morphological changes during Drosophila embryogenesis Public Deposited

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  • March 21, 2019
Creator
  • Jung, Kuo-chen
    • Affiliation: College of Arts and Sciences, Department of Biology
Abstract
  • The fundamental question for developmental biologists is to understand how fertilized eggs become mature multicellular adults. During this process, cells undergo morphogenesis to form different cell and tissue shapes. Accomplishing accurate morphogenesis in organisms requires several structural protein systems: polarity proteins define different membrane domains and cell polarity, a cytoskeletal network provides the driving force to modify cell shape, and adherens junctions (AJ) maintain whole tissue integrity. Linker proteins between the AJ and the cytoskeleton ensure coordinated cell morphological changes. In the Peifer lab, we use Drosophila as a system to study these events. Failure of proper cell morphological changes causes abnormal embryonic processes. I characterized cno phenotypes during dorsal closure to investigate Cno function in later developmental stages during Drosophila embryogenesis. I also examined Rap1 and Cno localization in different developmental stages to help understand how Rap1 and Cno function temporally.
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  • In Copyright
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  • ... in partial fulfillment of the requirements for the degree of Master of Science in the Department of Biology.
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  • Peifer, Mark
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