Microgenomics in ameloblastoma Public Deposited

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  • March 21, 2019
Creator
  • DeVilliers, Patricia
    • Affiliation: School of Dentistry
Abstract
  • Ameloblastoma, the second most common tumor arising from odontogenic epithelium of the jawbones, is characterized by a benign but locally invasive behavior with a high risk of recurrence. RNA was isolated and amplified from laser capture microdissected (AutoPix™) epithelial cells from five samples of formalin fixed decalcified paraffin embedded, (FFDPE) ameloblastoma tissue. The aminoallyl antisense RNA (aa-aRNA) was hybridized to 40,000-oligonucleotide expression microarrays and compared with Human Universal Reference RNA. Of the 210 significantly over-expressed genes, many were previously associated with tumor development, including Ras, cMic, Fos, WNT10A, FGF13 and T-cell acute lymphocytic leukemia 1. Other genes associated with tumor progression were also noted including Integrins, IL-17 , Spondin 2 and Beta adrenergic receptor kinase 2. Finally polymerase (DNA directed) gamma 2 , a DNA-repair gene product, was also up-regulated in ameloblastoma.
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  • In Copyright
Advisor
  • Wright, J. Timothy
Degree granting institution
  • University of North Carolina at Chapel Hill
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  • Open access
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