Dental Ankylosis: Clinical and Molecular Characterization Public Deposited

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  • March 20, 2019
Creator
  • Senties-Ramirez, Gabriel
    • Affiliation: School of Dentistry, Department of Orthodontics
Abstract
  • Introduction: Dental ankylosis is a histological definition for a condition that is often clinically indistinguishable from other eruption disorders. Confusion between ankylosis and PFE can result in an inaccurate diagnosis, and inappropriate orthodontic management. In this study, we tested the central hypothesis that ankylosis is a distinct pathology compared to PFE due to PTH1R mutations. Methods: 1) We completed mutational analysis of PTH1R on patients with PFE (based on familial segregation) or suspected ankylosis. 2) We performed expression studies to compare PFE and ankylosis in PDL tissue of control and affected extracted teeth. Collected PDL tissue from extracted teeth was used to create primary cell cultures for genetic expression studies. Differences in genetic expression of PTH1R, RANKL, BMP-2, BMP-4, and BMP-6 at the PDL between ankylosed, control, and PFE teeth were tested. Results: Differences in the expression of BMP-4, BMP-6, and PTH1R were found between control, PFE, and ankylosed teeth.
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  • In Copyright
Advisor
  • Wright, John
  • Ko, Ching-Chang
  • Frazier-Bowers, Sylvia
Degree
  • Master of Science
Degree granting institution
  • University of North Carolina at Chapel Hill Graduate School
Graduation year
  • 2016
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