Inducible nitric oxide synthase and periodontal inflammation: a preclinical canine study Public Deposited

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  • March 21, 2019
  • Arrington, Harriet L.
    • Affiliation: School of Dentistry, Department of Periodontology
  • Up-regulation of inducible nitric oxide synthase (iNOS) has been linked to periodontal disease and its progression. This preclinical study was therefore conducted to evaluate the effects of a selective iNOS inhibitor, INO-1001, on the initiation and progression of experimental gingivitis in the canine model. Following a safety and feasibility study, eighteen beagles were randomized to treatment with topically administered INO-1001 or placebo gels and experimental gingivitis was induced over an 8-week period. Clinical outcomes (i.e., plaque index, ginigival index, bleeding on probing and modified sulcular bleeding index) were measured at baseline, 4 and 8 weeks. No inter-group differences were noted at the baseline or 4- week examinations. At the 8-week exam, measures of gingival inflammation and sulcular ulceration were significantly increased in the INO-1001 group compared to placebo. These results suggest that iNOS may play a dual role in the pathogenesis of periodontal disease and may be critical for periodontal homeostasis.
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  • Paquette, David W.
  • Open access

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