Glycogen synthase kinase-3 is required for axon growth and development Public Deposited

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  • March 21, 2019
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  • Wang, Xinshuo
    • Affiliation: School of Medicine, Department of Cell Biology and Physiology
Abstract
  • Glycogen Synthase Kinase-3 (GSK-3) is a critical downstream regulator in multiple signaling pathways including neurotrophin/PI3K and Wnt/[beta]-catenin pathways. GSK-3 signal has been strongly implicated in the regulation of neuronal polarity and axon growth in vitro. However, how GSK-3 is regulated and whether it is required for mammalian nervous system development is unknown. Here, I assessed the role of Par6 signaling in the regulation of GSK-3 activity and NGF-induced axon growth. My results show that Par6 is required for GSK-3 phosphorylation and inhibition. Elimination of Par6 inhibits NGF-induced axon growth. We have also generated nervous system specific GSK-3 knockout mice. By studying GSK-3 null cortical neurons, my results show that GSK-3 is required for axon growth in vivo and the deletion of GSK-3 mainly affects the microtubule dynamics which prevents the axon growth. We conclude that GSK-3 is a key regulator of axon growth and development both in vivo and in vitro.
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  • Snider, William D.
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