Zhang, Shaoping. Expression of Interleukin-37 (il37) and the Genetic Variations of Il37 In Relation to Chronic Periodontitis. University of North Carolina at Chapel Hill, 2014. https://doi.org/10.17615/q8e3-0v87
Zhang, S. (2014). Expression of interleukin-37 (IL37) and the genetic variations of IL37 in relation to chronic periodontitis. University of North Carolina at Chapel Hill. https://doi.org/10.17615/q8e3-0v87
Zhang, Shaoping. 2014. Expression of Interleukin-37 (il37) and the Genetic Variations of Il37 In Relation to Chronic Periodontitis. University of North Carolina at Chapel Hill. https://doi.org/10.17615/q8e3-0v87
Affiliation: School of Dentistry, Department of Periodontology
Objectives: To study the transcription of IL37 in gingival biopsies and the association between transcription of IL1B, IL6 and IL37 and genotypes at the rs3811046 and rs3811047 IL37 loci. Materials and Methods: Gingival biopsies were collected from chronic periodontitis patients and control subjects. Pyrosequencing was applied for genotyping. Real-time PCR was used to examine the transcription of genes from biopsies and cell culture models. Results: Transcription of IL6 was significantly higher in periodontitis samples. Transcription of IL37 was induced in oral epithelial and THP.1 cells by LPS. The presence of a minor allele at both loci in IL37 was significantly related to a reduced IL6 transcription in Caucasians, while the major allele was associated with a higher transcription of IL6 in African Americans. Conclusion: Gingival epithelium and monocytic cells are the major source for IL-37. The genetic variants of IL37 related to the altered transcription of IL6 are race specific.