Exploring the Genetic Basis of Early Childhood Caries Public Deposited

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Last Modified
  • March 19, 2019
Creator
  • Ballantine, Jami
    • Affiliation: School of Dentistry, Department of Pediatric Dentistry
Abstract
  • Objectives: We sought to 1) determine the proportion of ECC variance explained by high-density genotyping of the human genome, and 2) identify associated genetic loci. Methods: The discovery sample comprised 212 children participating in the study (ZOE) in North Carolina. DNA was purified from saliva and genotyped using Illumina HumanOmni2.5-8 arrays. “Prioritized” SNPs with P<5x10-5 were examined for replication in 3 independent cohorts of preschool-age children from the COHRA (n=326), IFS (n=348) and IHS (n=247) studies. Results: Fifty-two percent (P=0.03) of ECC variance was explained by all SNPs with minor allele frequency ≥5%. We found no genome-wide significant association (P<5x10-8), but 13 loci had P<5x10-5. No locus met statistical significance criteria in the replication samples. Conclusion: These results affirm a heritable component of ECC and demonstrate the feasibility of conducting genomics studies among preschool-age children.
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  • In Copyright
Advisor
  • Divaris, Kimon
  • Agler, Cary
  • Zandona, Andrea
  • Roberts, Michael
Degree
  • Master of Science
Degree granting institution
  • University of North Carolina at Chapel Hill Graduate School
Graduation year
  • 2017
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