Exploring the Genetic Basis of Early Childhood Caries Public Deposited
- Last Modified
- March 19, 2019
- Creator
-
Ballantine, Jami
- Affiliation: School of Dentistry, Department of Pediatric Dentistry
- Abstract
- Objectives: We sought to 1) determine the proportion of ECC variance explained by high-density genotyping of the human genome, and 2) identify associated genetic loci. Methods: The discovery sample comprised 212 children participating in the study (ZOE) in North Carolina. DNA was purified from saliva and genotyped using Illumina HumanOmni2.5-8 arrays. “Prioritized” SNPs with P<5x10-5 were examined for replication in 3 independent cohorts of preschool-age children from the COHRA (n=326), IFS (n=348) and IHS (n=247) studies. Results: Fifty-two percent (P=0.03) of ECC variance was explained by all SNPs with minor allele frequency ≥5%. We found no genome-wide significant association (P<5x10-8), but 13 loci had P<5x10-5. No locus met statistical significance criteria in the replication samples. Conclusion: These results affirm a heritable component of ECC and demonstrate the feasibility of conducting genomics studies among preschool-age children.
- Date of publication
- May 2017
- Keyword
- DOI
- Resource type
- Rights statement
- In Copyright
- Advisor
- Divaris, Kimon
- Agler, Cary
- Zandona, Andrea
- Roberts, Michael
- Degree
- Master of Science
- Degree granting institution
- University of North Carolina at Chapel Hill Graduate School
- Graduation year
- 2017
- Language
- Parents:
This work has no parents.
Items
Thumbnail | Title | Date Uploaded | Visibility | Actions |
---|---|---|---|---|
|
Ballantine_unc_0153M_17088.pdf | 2019-04-11 | Public |
|