β2-adrenergic receptor modulation of macrophage inflammatory mediator production Public Deposited
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- Last Modified
- June 7, 2019
Snyder, Ellen Amanda
- Affiliation: School of Dentistry, Oral and Craniofacial Biomedicine PhD Program
- Research has demonstrated that the complex interaction between the nervous system and the immune system plays a critical role in maintaining homeostasis. The nervous system is capable of modulating the immune response via activation of β2-adrenergic receptors (β2-ARs) present on immunocompetent cells. Because macrophages are major mediators of the immune response, several investigators have sought to determine the effect of β2-AR stimulation upon inflammatory mediator production by these cells. Traditionally, scientists have regarded β2-AR activity as anti-inflammatory since stimulation of these receptors inhibits LPS-induced production of inflammatory molecules. However, a thorough review of existing literature reveals several publications suggesting β2-AR activation may actually have pro-inflammatory effects upon macrophage response. Importantly, β2-AR drugs are often used to treat various diseases, including several diseases of inflammatory origin. As a result, recognizing the dual immunomodulatory potential of β2-ARs is necessary to fully understand the inflammatory impact of β2-AR drugs in therapy.
- Date of publication
- December 2007
- Resource type
- Rights statement
- In Copyright
- Flood, Patrick M.
- Degree granting institution
- University of North Carolina at Chapel Hill
- Open access
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|[beta]2-adrenergic receptor modulation of macrophage inflammatory mediator production||2019-04-11||Public||