Comparison Among CPP-ACP, Fluoride and a Combination of CPP-ACP/Fluoride and Their Ability to Remineralize White Spot Lesions in vitro Public Deposited

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  • March 20, 2019
  • Oliveira, Gustavo Mussi Stefan
    • Affiliation: School of Dentistry, Department of Operative Dentistry
  • This study evaluated the ability of a casein-phosphopeptide amorphous-calcium-phosphate paste (CPP-ACP, MI PasteTM), a 1.1% NaF toothpaste containing 5000 ppm of fluoride (ControlRXTM) and a CPP-ACP paste with 900 ppm of fluoride (MI Paste PlusTM) to remineralize white spot lesions in vitro. Thirty five crowns of sound human molars were sectioned into four specimens. Artificial white spot lesions were formed in all specimens. Specimens were then randomly assigned to one of the following remineralizing treatments (n=35) with a pH-cycling model over 30 days: Group 1 - Control; Group 2 - MIPaste; Group 3 - F5000; Group 4 - MI Paste Plus. Therapeutic agents were applied following the manufacturers' directions. MicroCT and Light-induced fluorescence were used as methods of assessment. The outcome measures were Lesion Volume (p=0.185), Lesion Density (p=0.048), Mean Fluorescence Loss (p<0.001), and Area of the Lesion (p<0.001). Overall, the 1.1% NaF containing toothpaste demonstrated better remineralization ability than CPP-ACP products overtime.
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  • In Copyright
  • "... in partial fulfillment of the requirements for the degree of Masters of Sciences in the Department of Operative Dentistry."
  • Wright, J. Timothy
Place of publication
  • Chapel Hill, NC
  • Open access

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