Obesity as a potential modifier for periodontal infection pathogenesis Public Deposited

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  • March 22, 2019
Creator
  • Perri, Romina
    • Affiliation: School of Dentistry, Department of Periodontology
Abstract
  • The overall aim of this study was to examine the association between periodontal disease and obesity. This relationship was assessed at the epidemiologic level using a cross-sectional observation study with 6780 participants from the Atherosclerosis Risk in Communities (ARIC) study and at the molecular level by further investigating the impact of obesity on periodontal pathogenesis via changes in differential microRNA expression. Findings from the ARIC study indicated that important associations between diabetes and periodontal disease and obesity exist. Increased likelihood for gingivitis was identified in both patients with diabetes and an obese BMI. Reaffirmation of the critical role of CRP and IL-6 on systemic inflammatory burden was shown in an obese population. Eleven unique miRNAs were up-regulated (miR-15a, -18a, -22, -30d, -30e, -103, -106b, -130a, -142-3p, -185, -210) in the obese patients with periodontal disease. Sixty-nine different genes with miRNA target sequences were identified which included proinflammatory cytokines/chemokines, proteins involved in collagen formation, glucose and lipid metabolism. The miRNAs identified in this study may play a crucial role in the pathogenesis of periodontal infection modified by obesity as well as provide a basis for further investigations regarding the effect of obesity on periodontal pathogenesis.
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  • ... in partial fulfillment of the requirements of the Master of Science in the Department of Periodontology, School of Dentistry.
Advisor
  • Barros, Silvana
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