Synthesis, characterization and applications of new photocurable and biodegradable elastomers Public Deposited

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Last Modified
  • March 21, 2019
Creator
  • Liu, Jinrong
    • Affiliation: College of Arts and Sciences, Department of Applied Physical Sciences, Materials Science Graduate Program
Abstract
  • Biodegradable elastomers have attracted a great deal of interest due to their potential applications in the biomedical field. Based on the advantages of the photocuring method, a new series of photocurable and biodegradable elastomers were designed. By using step growth polymerization, polyester liquids with different composition and molecular weights were synthesized. After endcapping with methacrylate groups, these liquids can be easily fabricated into completely amorphous elastomers by UV exposure for 1 min at room conditions. The prepared elastomers presented a wide range of mechanical properties (G equals 0.1-10 MPa) and a fast degradation rate (16 percent after 5 week incubation in PBS). The in vitro and in vivo biocompatibility studies of the elastomers indicated that these elastomers were good candidates as tissue engineering scaffolds. Meanwhile, the functionality of these photocurable elastomers was expanded by incorporation of amine containing monomers, and new elastomers were prepared to explore their potential as drug carrier systems. Monodispersed elastomeric particles were fabricated out of these amine containing materials by PRINTTM technology. These particles showed pH sensitive drug release of Doxorubicin (a hydrophobic drug model) and Minocycline chloride (a hydrophilic drug model), and the release profiles can be further tuned by the incorporation of a disulfide crosslinker.
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  • In Copyright
Advisor
  • Ashby, Valerie
Degree granting institution
  • University of North Carolina at Chapel Hill
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  • Open access
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