Investigating the Etiology of the Short Root Anomaly Public Deposited

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Last Modified
  • March 19, 2019
Creator
  • Hill, Ashley
    • Affiliation: School of Dentistry, Department of Orthodontics
Abstract
  • Objectives: Short Root Anomaly (SRA) is an emerging clinical problem but the clinical features and etiology are poorly understood. In order to test the hypothesis that one or more genes contribute to the SRA phenotype, we aimed to 1) characterize the SRA phenotype and its associated risk for orthodontically induced external apical root resorption (OIEARR) and 2) complete mutational analysis. Methods: The affected teeth and presence of other dental anomalies was assessed. PCR based mutational analysis was completed for 9 SRA samples for BMP4, BMP2, NFI-C and PTH1R. Pre- and post-treatment panoramic radiographs for 7 patients were evaluated for incidence and severity of OIEARR of SRA affected maxillary central incisors. Results: We identified 3 broad types of SRA and 5 SNPs. OIEARR was observed in 64% of affected maxillary central incisors. Mild resorption was observed in 50%, moderate resorption was observed in 7% and severe resorption was observed in 7% of teeth. Conclusions: SRA can present as three distinct phenotypes. SRA affected maxillary central incisors are not more susceptible to OIEARR or severe root resorption.
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  • In Copyright
Advisor
  • Tyndall, Donald
  • Frazier-Bowers, Sylvia
  • Koroluk, Lorne
  • Wright, J. Timothy
Degree
  • Master of Science
Degree granting institution
  • University of North Carolina at Chapel Hill Graduate School
Graduation year
  • 2017
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