Histories of depression, allopregnanolone responses to stress, and premenstrual symptoms in women Public Deposited

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  • March 20, 2019
  • Klatzkin, Rebecca R.
    • Affiliation: College of Arts and Sciences, Department of Psychology and Neuroscience
  • Twenty-six women with premenstrual dysphoric disorder (PMDD) and 39 non-PMDD women were tested for allopregnanolone (ALLO) responses to mental stress. Fourteen PMDD and 17 non-PMDD women had a history of depression (DEP), though all were free of current psychiatric illness. Women with prior DEP showed a blunted ALLO stress response and failed to show a decrease from venipuncture to baseline compared to women with no prior DEP. Women with prior DEP did not show the correlation between progesterone and ALLO that was seen in those with no prior DEP. ALLO levels at baseline and blunted ALLO reactivity predicted more severe premenstrual symptoms, but only in PMDD women with prior DEP. These results suggest that prior DEP is associated with a failure of ALLO to be appropriately responsive to challenge, with alterations in the conversion of progesterone to ALLO, and link ALLO to symptoms in PMDD women with prior DEP.
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  • In Copyright
  • Girdler, Susan S.
  • Open access

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