Characteristics and the Stable Nebulization of a Molecule Against SARS-CoV-2
Public Deposited- Creator
-
Ma, Alice
- Affiliation: School of Medicine, Joint Department of Biomedical Engineering, North Carolina State University
- Abstract
- The SARS-CoV-2 virus, the causative agent of COVID-19, emerged at the end of 2019 and since then has created a massive global pandemic, with over 220 million cases and more than 4 million deaths worldwide. Though effective vaccines and treatments have been introduced, variants and mutations of the virus continue to emerge and evade current therapeutics, thus necessitating a need for an effective viral therapy that is able to neutralize SARS-CoV-2 and its variants. We developed an ACE2-linker-Fc molecule that is not only able to bind the wild type SARS-CoV-2 S protein with high, picomolar affinity, but is also able to bind to several variants of the virus, as well. This molecule is also able to be stably nebulized using a commercial vibrating mesh nebulizer, lending to its capability of being an effective inhaled immunotherapy for SARS-CoV-2, its current and future variants, as well as other similar respiratory viruses.
- Date of publication
- 2021
- Keyword
- DOI
- Resource type
- Rights statement
- In Copyright - Educational Use Permitted
- Advisor
- Lai, Samuel K
- Zaharoff, David
- Pickles, Raymond
- Degree
- Master of Science
- Degree granting institution
- University of North Carolina at Chapel Hill Graduate School
- Graduation year
- 2021
- Language
Relations
- Parents:
- In Collection:
This work has no parents.
Items
| Thumbnail | Title | Date Uploaded | Visibility | Actions |
|---|---|---|---|---|
|
|
Ma_unc_0153M_20488.pdf | 2022-01-10 | Public | Download |