Innovative biomedical applications using hybrid nanoparticles Public Deposited

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Last Modified
  • March 21, 2019
Creator
  • Kim, Jason Sung
    • Affiliation: College of Arts and Sciences, Department of Chemistry
Abstract
  • Nanoparticle and metal-chelate technologies can be combined to create innovative hybrid materials with versatile functions for research and clinical purposes. This dissertation addresses the novel use of hybrid inorganic/organic nanoparticles in biomedical applications, including early detection of autoimmune disease and cancer as well as purification of therapeutic proteins. In an in vivo animal model of rheumatoid arthritis (RA), fluorescent nanoparticles coated with a magnetic resonance imaging (MRI) contrast enhancing metalchelate are used for cell specific trafficking of monocytes, which correlate with disease activity. Metal-chelate derivatized magnetic nanoparticles isolate tagged proteins, potential cancer therapeutics, from impurities generated from bacterial and mammalian cell expression systems. The novel applications of hybrid magnetic nanoparticles pursued in this dissertation have the ability to translate into new and more sensitive strategies to treat patients with chronic disease.
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  • In Copyright
Advisor
  • Lin, Wenbin
Degree granting institution
  • University of North Carolina at Chapel Hill
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  • Open access
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