Stromal promotion of metastasis by erythroid differentiation regulator 1 Public Deposited

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Last Modified
  • March 21, 2019
Creator
  • Mango, Robert L.
    • Affiliation: School of Medicine, Department of Microbiology and Immunology
Abstract
  • Stromal cells and the various factors they release play an important role in the promotion of tumor growth and metastasis. The construction of a supportive tumor stroma involves the recruitment and activation of multiple cell types. CC-chemokine receptor 5 (CCR5) enhances the ability of pulmonary mesenchymal cells (PMCs) to promote metastasis of melanoma cells to the lung, by inducing PMC migration and altering gene expression. In a screen of CCR5-depedent gene expression changes during early metastatic colonization, Erythroid differentiation regulator 1 (Erdr1) was identified as a potential pro-metastatic factor. While its biochemical mechanism of action has not been fully characterized, Erdr1 has been shown to act as a survival factor for several types of hematopoietic cells. The role of Erdr1 in stromal promotion of metastasis was investigated, and Erdr1 expression in both mouse and human cells was characterized. The results indicate that Erdr1 is a highly conserved gene which is expressed in mouse PMCs upon stimulation of CCR5, and which promotes metastasis by enhancing stromal cell survival. This represents a novel mechanism by which chemokine signaling in stromal cells influences the formation of metastasis, and establishes Erdr1 as a potentially important regulator of stromal cell processes in both mice and humans.
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  • In Copyright
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  • "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Microbiology and Immunology."
Advisor
  • Serody, Jonathan
Degree granting institution
  • University of North Carolina at Chapel Hill
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Place of publication
  • Chapel Hill, NC
Access
  • Open access
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