Last Modified

• March 20, 2019

Creator

• Valentine, Justin
  • Affiliation: School of Dentistry, Department of Periodontology

Abstract

• OBJECTIVE: The aim of this study was to determine active periodontal disease status in HIV and to determine the impact of periodontal disease resolution on HIV status. METHODS: In this longitudinal cohort study, 73 HIV-positive subjects received comprehensive dental care. AAP, CDC/AAP, and BGI case definitions determined periodontal classification. Likelihood and frequency of moderate/severe periodontal disease were assessed based on demographic variables. The influence of periodontal intervention was assessed at baseline, 12, and 24 months. IL-6 was measured in a subset of subjects. RESULTS: Of the periodontal classifications, BGI demonstrated the highest percentage category improvement with the intervention (>50%). Moderate/severe periodontitis was positively associated HIV regardless of race, smoking status, gender, income level, and age, and was associated with increased IL-6. At baseline, the majority of subjects had severe periodontal disease regardless of ART status. Subjects with suppressed viral load at baseline demonstrated a significant improvement in BGI classification (P = 0.026), increased CD4 counts (P = 0.027), and decreased IL-6 levels (P = 0.03). CONCLUSIONS: Periodontal inflammation was prevalent regardless of ART status. In virologically suppressed subjects, the intervention decreased periodontitis with a concomitant IL-6 decrease and CD4 increase. These findings suggest a relationship between periodontal inflammation, oral microbial translocation, and HIV status.

Date of publication

• May 2016

Keyword

• Microbial Translocation
• Dentistry
• Human Immunodeficiency Virus
• Periodontal disease
• Virology
• Inflammation

DOI

• https://doi.org/10.17615/z68c-w826

Resource type

• Masters Thesis

Rights statement

• In Copyright

Advisor

• Webster-Cyriaque, Jennifer
• Southerland, Janet
• Morelli, Thiago

Degree

• Master of Science

Degree granting institution

• University of North Carolina at Chapel Hill Graduate School

Graduation year

• 2016

Language

• English

Parents:

This work has no parents.

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