Total synthesis of irciniastatin A Public Deposited

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Last Modified
  • March 22, 2019
Creator
  • Stevens, Jason M.
    • Affiliation: College of Arts and Sciences, Department of Chemistry
Abstract
  • The total synthesis of (+)-irciniastatin A (psymberin) is reported in 19 steps and 6% overall yield. Key reactions include a highly convergent enolsilane-oxocarbenium ion union to generate the C8-C25 fragment and a late-stage coupling of a hemiaminal and acid chloride to complete the synthesis. In addition, efforts toward a second generation formal synthesis are described.
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  • In Copyright
Advisor
  • Crimmins, Michael T.
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