Total synthesis of irciniastatin A Public Deposited
- Last Modified
- March 22, 2019
- Creator
-
Stevens, Jason M.
- Affiliation: College of Arts and Sciences, Department of Chemistry
- Abstract
- The total synthesis of (+)-irciniastatin A (psymberin) is reported in 19 steps and 6% overall yield. Key reactions include a highly convergent enolsilane-oxocarbenium ion union to generate the C8-C25 fragment and a late-stage coupling of a hemiaminal and acid chloride to complete the synthesis. In addition, efforts toward a second generation formal synthesis are described.
- Date of publication
- May 2010
- DOI
- Resource type
- Rights statement
- In Copyright
- Advisor
- Crimmins, Michael T.
- Language
- Access
- Open access
- Parents:
This work has no parents.
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Total synthesis of irciniastatin A | 2019-04-10 | Public |
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